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Objective <p>This study examines annual trends and regional disparities in interventions and in-hospital outcomes for trisomies 18 and 13.</p> Study design <p>We conducted a retrospective cohort study using nationwide data from 2011 to 2022. Patients with trisomies 18 and 13 admitted on the day of birth were identified. Nonsurgical and surgical intervention rates, survival to discharge, length of stay, and costs were analyzed by year and region.</p> Result <p>This study identified 2 245 neonates with trisomy 18 (<i>n</i> = 1 808) and trisomy 13 (<i>n</i> = 437). Nonsurgical and surgical intervention rates increased annually. Between 2011 and 2022, survival to discharge rates improved from 44.5 to 57.9%, and both hospital length of stay and costs nearly doubled. Regional disparities in survival to discharge rates were significant, with differences of up to 21.5%.</p> Conclusion <p>We observed an increase in interventions and a corresponding improvement in survival to discharge, with significant regional variations.</p>

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Annual trends and regional variations in medical interventions and survival to discharge for trisomies 18 and 13, 2011–2022: a nationwide inpatient database study

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • Shunya Sugai,
  • Yusuke Sasabuchi,
  • Mina Itsukaichi,
  • Akira Kobayashi,
  • Hideo Yasunaga,
  • Yuya Kimura,
  • Hiroki Matsui,
  • Kiyohide Fushimi,
  • Koji Nishijima,
  • Kosuke Yoshihara

摘要

Objective

This study examines annual trends and regional disparities in interventions and in-hospital outcomes for trisomies 18 and 13.

Study design

We conducted a retrospective cohort study using nationwide data from 2011 to 2022. Patients with trisomies 18 and 13 admitted on the day of birth were identified. Nonsurgical and surgical intervention rates, survival to discharge, length of stay, and costs were analyzed by year and region.

Result

This study identified 2 245 neonates with trisomy 18 (n = 1 808) and trisomy 13 (n = 437). Nonsurgical and surgical intervention rates increased annually. Between 2011 and 2022, survival to discharge rates improved from 44.5 to 57.9%, and both hospital length of stay and costs nearly doubled. Regional disparities in survival to discharge rates were significant, with differences of up to 21.5%.

Conclusion

We observed an increase in interventions and a corresponding improvement in survival to discharge, with significant regional variations.