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Objective <p>Preterm infants have pulmonary ventilation and perfusion abnormalities, yet few imaging modalities can inform clinicians about this ventilation/perfusion (V/Q) relationship. Electrical impedance tomography (EIT) is an imaging technique with V/Q imaging capabilities that has not been well described in infants with BPD.</p> Study design <p>EIT was performed every 4 weeks in preterm infants for a maximum of 5 visits per infant. Term infants with healthy lungs had one EIT imaging visit as controls.</p> Results <p>Data were collected from a total of 51 EIT visits. Novel V/Q maps were generated from each visit. Ventilation heterogeneity (measured by the global inhomogeneity index) and V/Q heterogeneity (measured by coefficient of variation of V/Q maps) were significantly higher in preterm infants at the visit closest to 36 weeks post-menstrual age than controls (<i>p</i> = 0.002 and <i>p</i> = 0.039, respectively).</p> Conclusions: <p>Pulmonary ventilation, perfusion, and V/Q relationship can be quantified by EIT, and may be indicators of chronic lung disease.</p>

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Electrical impedance tomography reveals ventilation and perfusion heterogeneity in infants with bronchopulmonary dysplasia

  • 期刊论文

  • 发表日期：

    2026年2月24日

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  • Katelyn G. Enzer,
  • Nilton Barbosa Da Rosa Jr,
  • Allison Keck,
  • Ella Hagopian,
  • John T. Brinton,
  • Omid Rajabi Shishvan,
  • Gary Saulnier,
  • David Isaacson,
  • Jennifer L. Mueller,
  • Christopher D. Baker

摘要

Objective

Preterm infants have pulmonary ventilation and perfusion abnormalities, yet few imaging modalities can inform clinicians about this ventilation/perfusion (V/Q) relationship. Electrical impedance tomography (EIT) is an imaging technique with V/Q imaging capabilities that has not been well described in infants with BPD.

Study design

EIT was performed every 4 weeks in preterm infants for a maximum of 5 visits per infant. Term infants with healthy lungs had one EIT imaging visit as controls.

Results

Data were collected from a total of 51 EIT visits. Novel V/Q maps were generated from each visit. Ventilation heterogeneity (measured by the global inhomogeneity index) and V/Q heterogeneity (measured by coefficient of variation of V/Q maps) were significantly higher in preterm infants at the visit closest to 36 weeks post-menstrual age than controls (p = 0.002 and p = 0.039, respectively).

Conclusions:

Pulmonary ventilation, perfusion, and V/Q relationship can be quantified by EIT, and may be indicators of chronic lung disease.