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Background <p>Intermittent hypoxemia events (IH) in preterm infants may alter airway function manifesting as childhood wheezing.</p> Objective <p>Characterize the relationship between IH (first month of life) and wheezing through 12/24 months corrected age.</p> Study design <p>IH &lt; 80% and &lt;90% and number of wheezing episodes were documented in infants &lt;31 weeks gestation discharged prior to and during COVID-19 social isolation.</p> Results <p>A greater % time with hypoxemia was associated with increased rates of wheezing through 12 months in infants discharged during COVID-19, (IRRs ranging from 1.07 to 1.32, IH &lt; 80 and 90%, all <i>p </i>&lt; 0.05) and through 24 months in infants &lt;28wks GA discharged during COVID-19 isolation (IRRs, 1.03–1.25, IH &lt; 80 and 90%, all <i>p</i> &lt; 0.05).</p> Conclusion <p>Associations were seen between IH and wheezing at 12 and 24 months of age predominantly in infants discharged during COVID-19 isolation. No associations were seen through 12 months corrected age in infants discharged during the Pre COVID-19 epoch.</p>

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Association between intermittent hypoxemia and COVID-19 related isolation and pulmonary outcomes through 2 years of age in infants born preterm

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  • 发表日期：

    2025年12月8日

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  • Juliann M. Di Fiore,
  • Zhengyi Chen,
  • Nori Minich,
  • Deanne Wilson-Costello,
  • Richard J. Martin,
  • Anna Maria Hibbs

摘要

Background

Intermittent hypoxemia events (IH) in preterm infants may alter airway function manifesting as childhood wheezing.

Objective

Characterize the relationship between IH (first month of life) and wheezing through 12/24 months corrected age.

Study design

IH < 80% and <90% and number of wheezing episodes were documented in infants <31 weeks gestation discharged prior to and during COVID-19 social isolation.

Results

A greater % time with hypoxemia was associated with increased rates of wheezing through 12 months in infants discharged during COVID-19, (IRRs ranging from 1.07 to 1.32, IH < 80 and 90%, all p < 0.05) and through 24 months in infants <28wks GA discharged during COVID-19 isolation (IRRs, 1.03–1.25, IH < 80 and 90%, all p < 0.05).

Conclusion

Associations were seen between IH and wheezing at 12 and 24 months of age predominantly in infants discharged during COVID-19 isolation. No associations were seen through 12 months corrected age in infants discharged during the Pre COVID-19 epoch.