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Objective <p>To examine associations between oxidative stress and fetal weight across pregnancy.</p> Study design <p>Cohort study of pregnant participants from 2016-2021 in New York City with urinary lipid, protein, and DNA oxidative stress biomarkers (&lt;18, 18–25, &gt;25 weeks) and estimated fetal weight from ultrasound fetal biometry with the HadlockIII formula (20, 30, 36 weeks).</p> Result <p>Among 1408 participants, oxidative stress biomarkers of lipid peroxidation and DNA damage were associated with smaller estimated fetal weight at 30 and 36 weeks (ranging from B = –3.9 grams/unit increase [95% CI: –6.9, –0.9; <i>8,15</i> − <i>PGF2α</i>] to –20.3 [95% CI: –27.9, –12.8; <i>8</i> − <i>OHdG</i>]), particularly among fetuses at the 25<sup>th</sup> percentile. Oxidative stress biomarkers of protein damage were associated with larger estimated fetal weight at 20 (3.4 [95% CI: 1.2, 5.7]) and 36 weeks (16.5 [95% CI: 5.2, 27.8]).</p> Conclusion <p>These findings advance our understanding of different oxidative stress pathways and their potential role in fetal growth.</p>

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Oxidative stress and fetal weight: observational findings from a pregnancy cohort in New York City

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月11日

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  • Carol Duh-Leong,
  • Akhgar Ghassabian,
  • Whitney Cowell,
  • Sarvenaz Shahin,
  • Mengling Liu,
  • Kurunthachalam Kannan,
  • Kristyn A. Pierce,
  • Shilpi S. Mehta-Lee,
  • Sara E. Long,
  • Yuyan Wang,
  • Wenqing Yang,
  • Yelena Afanasyeva,
  • Leonardo Trasande

摘要

Objective

To examine associations between oxidative stress and fetal weight across pregnancy.

Study design

Cohort study of pregnant participants from 2016-2021 in New York City with urinary lipid, protein, and DNA oxidative stress biomarkers (<18, 18–25, >25 weeks) and estimated fetal weight from ultrasound fetal biometry with the HadlockIII formula (20, 30, 36 weeks).

Result

Among 1408 participants, oxidative stress biomarkers of lipid peroxidation and DNA damage were associated with smaller estimated fetal weight at 30 and 36 weeks (ranging from B = –3.9 grams/unit increase [95% CI: –6.9, –0.9; 8,15 − PGF2α] to –20.3 [95% CI: –27.9, –12.8; 8 − OHdG]), particularly among fetuses at the 25th percentile. Oxidative stress biomarkers of protein damage were associated with larger estimated fetal weight at 20 (3.4 [95% CI: 1.2, 5.7]) and 36 weeks (16.5 [95% CI: 5.2, 27.8]).

Conclusion

These findings advance our understanding of different oxidative stress pathways and their potential role in fetal growth.