Scholarlink

Objective <p>To determine associations of human milk lactoferrin concentrations with growth outcomes in very preterm infants.</p> Study design <p>In 63 infants &lt;32 weeks’ gestation, human milk samples on days 14 and 28 were analyzed for lactoferrin using electrochemiluminescence multiplex immunoassay, and values were averaged to generate mean concentrations. Anthropometry and body composition were measured at term-corrected age. Median regression was used to test median differences in outcomes across tertiles of mean human milk lactoferrin levels [lowest (0.06–0.13 mg/mL) vs. middle (0.14–0.22 mg/mL) and highest (&gt;0.22 mg/mL)].</p> Results <p>Compared to infants in the lowest tertile of human milk lactoferrin concentration, those in the highest tertile had greater head circumference z-score (β = 0.81 z-scores per mg/mL; 95% CI = 0.2, 1.4). There were no other differences between groups.</p> Conclusion <p>Human milk lactoferrin concentrations were positively associated with head circumference z-scores during hospitalization. Future studies should examine the safety/utility of lactoferrin supplementation to optimize head growth.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Associations of human milk lactoferrin with measures of physical growth in very preterm infants

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月31日

查看全文
  • Paige K. Berger,
  • Manasa Kuncham,
  • Margaret L. Ong,
  • Katherine Bell,
  • Anne CC Lee,
  • Sarbattama Sen,
  • Annalee Furst,
  • Lars Bode,
  • Mandy B. Belfort

摘要

Objective

To determine associations of human milk lactoferrin concentrations with growth outcomes in very preterm infants.

Study design

In 63 infants <32 weeks’ gestation, human milk samples on days 14 and 28 were analyzed for lactoferrin using electrochemiluminescence multiplex immunoassay, and values were averaged to generate mean concentrations. Anthropometry and body composition were measured at term-corrected age. Median regression was used to test median differences in outcomes across tertiles of mean human milk lactoferrin levels [lowest (0.06–0.13 mg/mL) vs. middle (0.14–0.22 mg/mL) and highest (>0.22 mg/mL)].

Results

Compared to infants in the lowest tertile of human milk lactoferrin concentration, those in the highest tertile had greater head circumference z-score (β = 0.81 z-scores per mg/mL; 95% CI = 0.2, 1.4). There were no other differences between groups.

Conclusion

Human milk lactoferrin concentrations were positively associated with head circumference z-scores during hospitalization. Future studies should examine the safety/utility of lactoferrin supplementation to optimize head growth.