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Objective <p>To assess the risk of infant exposure to illicit and prescription drug residues, from infant-ready, pooled, pasteurized donor human milk (PDHM) provided by healthy, screened, voluntary non-remunerated donors to a not-for-profit milk bank.</p> Study design <p>A total of 150 pooled samples, representing 742 donor contributions, were analyzed for 15 illicit and prescription drug analytes using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Detected concentrations were evaluated for clinical significance.</p> Result <p>All 150 PDHM samples tested negative for residues of marijuana, amphetamines, benzodiazepines, fentanyl, hydrocodone, and morphine. Three samples (2%) contained trace amounts of oxycodone (&lt;0.6 parts per billion), yielding exposures over 455 times lower than established standards for infant safety (Relative Infant Dose: &lt;0.022%; standard safety threshold 10%).</p> Conclusion <p>Comprehensive analysis detected no clinically relevant illicit or prescription drug residues in infant-ready pasteurized donor human milk, supporting both its safety for neonatal consumption and the effectiveness of current donor screening protocols and milk processing practices.</p>

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Quantification of illicit and prescription drug residues in pasteurized donor human milk: a comprehensive analytical approach

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月9日

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  • Michelle Brenner,
  • Kaytlin Krutsch,
  • Ashlynn Baker,
  • Dhavalkumar Patel,
  • Palika Datta

摘要

Objective

To assess the risk of infant exposure to illicit and prescription drug residues, from infant-ready, pooled, pasteurized donor human milk (PDHM) provided by healthy, screened, voluntary non-remunerated donors to a not-for-profit milk bank.

Study design

A total of 150 pooled samples, representing 742 donor contributions, were analyzed for 15 illicit and prescription drug analytes using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Detected concentrations were evaluated for clinical significance.

Result

All 150 PDHM samples tested negative for residues of marijuana, amphetamines, benzodiazepines, fentanyl, hydrocodone, and morphine. Three samples (2%) contained trace amounts of oxycodone (<0.6 parts per billion), yielding exposures over 455 times lower than established standards for infant safety (Relative Infant Dose: <0.022%; standard safety threshold 10%).

Conclusion

Comprehensive analysis detected no clinically relevant illicit or prescription drug residues in infant-ready pasteurized donor human milk, supporting both its safety for neonatal consumption and the effectiveness of current donor screening protocols and milk processing practices.