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Objective <p>To assess the feasibility of electrical impedance tomography (EIT) guided positive end-expiratory pressure (PEEP) titration to identify optimal PEEP in infants with severe bronchopulmonary dysplasia (BPD).</p> Study design <p>Case series of five EIT guided PEEP titrations in infants with severe BPD compared to a case series of five infants, without lung disease, requiring intubation. Optimal PEEP was identified as minimal percentage of lung overdistension and collapse. Lung function, bedside ventilatory and clinical data were tracked post EIT guided optimal PEEP titration.</p> Result <p>Four out of the five EIT assessments in infants with BPD identified an optimal PEEP that was sustained for at least three weeks. Three of the four successful assessments led to a decrease in PEEP, compared to baseline, and one confirmed the baseline PEEP was optimal.</p> Conclusion <p>EIT assessments can be a novel tool to aide identification of optimal PEEP in infants with heterogeneous lung disease.</p>

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Identifying optimal positive end-expiratory pressure with electrical impedance tomography guidance in severe bronchopulmonary dysplasia

  • 期刊论文

  • 发表日期：

    2025年9月30日

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  • Jessica E. Shui,
  • Carolyn J. LaVita,
  • Glasiele C. Alcala,
  • John H. Nichols,
  • Romal K. Jassar,
  • Rodica M. Turcu,
  • Paul H. Lerou,
  • Maurizio F. Cereda,
  • Ryan W. Carroll,
  • Roberta Ribeiro De Santis Santiago,
  • Lorenzo Berra

摘要

Objective

To assess the feasibility of electrical impedance tomography (EIT) guided positive end-expiratory pressure (PEEP) titration to identify optimal PEEP in infants with severe bronchopulmonary dysplasia (BPD).

Study design

Case series of five EIT guided PEEP titrations in infants with severe BPD compared to a case series of five infants, without lung disease, requiring intubation. Optimal PEEP was identified as minimal percentage of lung overdistension and collapse. Lung function, bedside ventilatory and clinical data were tracked post EIT guided optimal PEEP titration.

Result

Four out of the five EIT assessments in infants with BPD identified an optimal PEEP that was sustained for at least three weeks. Three of the four successful assessments led to a decrease in PEEP, compared to baseline, and one confirmed the baseline PEEP was optimal.

Conclusion

EIT assessments can be a novel tool to aide identification of optimal PEEP in infants with heterogeneous lung disease.