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Objective <p>A study of the safety of endotracheal tube exchange and its impact on pulmonary mechanics in preterm infants with chronic lung disease.</p> Study design <p>This retrospective cohort study included 67 infants born at less than 29 weeks gestational age who underwent endotracheal (ETT) exchange after 28 days of life in a Level 4 NICU between 2017 and 2023. Descriptive analysis was performed using the Wilcoxon rank-sum test and Chi-squared or Fisher’s exact tests to characterize the cohort and compare variables before and after the ETT exchange.</p> Results <p>ETT exchange led to increased stability in 60% of cases, while adverse events occurred in 57% of exchanges. By 36 weeks postmenstrual age, 92% of the cohort developed type 2 or 3 bronchopulmonary dysplasia (BPD).</p> Conclusion <p>The majority of ETT exchanges resulted in increased stability; however, the adverse event rate was high. Further studies are needed to determine whether ETT exchange improves long-term outcomes.</p>

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Endotracheal tube exchange in preterm infants with evolving chronic lung disease: safety, outcomes, and impacts on pulmonary mechanics

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • Mackenzie Parker,
  • Rebecca Shay,
  • Blair W. Weikel,
  • Kathleen Hannan

摘要

Objective

A study of the safety of endotracheal tube exchange and its impact on pulmonary mechanics in preterm infants with chronic lung disease.

Study design

This retrospective cohort study included 67 infants born at less than 29 weeks gestational age who underwent endotracheal (ETT) exchange after 28 days of life in a Level 4 NICU between 2017 and 2023. Descriptive analysis was performed using the Wilcoxon rank-sum test and Chi-squared or Fisher’s exact tests to characterize the cohort and compare variables before and after the ETT exchange.

Results

ETT exchange led to increased stability in 60% of cases, while adverse events occurred in 57% of exchanges. By 36 weeks postmenstrual age, 92% of the cohort developed type 2 or 3 bronchopulmonary dysplasia (BPD).

Conclusion

The majority of ETT exchanges resulted in increased stability; however, the adverse event rate was high. Further studies are needed to determine whether ETT exchange improves long-term outcomes.