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Objective <p>Characteristics associated with extubation success (ES) in established grade 3 bronchopulmonary dysplasia (G3-BPD) are unknown. The respiratory severity score (RSS) is associated with extubation failure in younger preterm infants and adverse outcomes in established BPD. We evaluated the association between the RSS and ES in G3-BPD.</p> Study design <p>Retrospective observational study of infants diagnosed with G3-BPD undergoing their first extubation attempt after 36 weeks postmenstrual age (PMA). Bivariable and multivariable logistic regression models were used to determine the associations between RSS and ES while adjusting for confounding characteristics.</p> Results <p>Among 239 infants with G3-BPD undergoing an extubation attempt with a median RSS of 3.0, 142 (59%) were successful. A higher RSS was associated with lower odds of ES in adjusted analysis.</p> Conclusion <p>RSS is independently associated with ES in infants with established G3-BPD undergoing their first extubation attempt after 36 weeks PMA, with lower odds of success as RSS increases.</p>

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Association between the respiratory severity score and extubation success in severe bronchopulmonary dysplasia

  • 期刊论文

  • 发表日期：

    2025年8月21日

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  • Avery W. Zierk,
  • Kathleen A. Gibbs,
  • Timothy D. Nelin,
  • Matthew Huber,
  • Scott A. Lorch,
  • Nicolas A. Bamat

摘要

Objective

Characteristics associated with extubation success (ES) in established grade 3 bronchopulmonary dysplasia (G3-BPD) are unknown. The respiratory severity score (RSS) is associated with extubation failure in younger preterm infants and adverse outcomes in established BPD. We evaluated the association between the RSS and ES in G3-BPD.

Study design

Retrospective observational study of infants diagnosed with G3-BPD undergoing their first extubation attempt after 36 weeks postmenstrual age (PMA). Bivariable and multivariable logistic regression models were used to determine the associations between RSS and ES while adjusting for confounding characteristics.

Results

Among 239 infants with G3-BPD undergoing an extubation attempt with a median RSS of 3.0, 142 (59%) were successful. A higher RSS was associated with lower odds of ES in adjusted analysis.

Conclusion

RSS is independently associated with ES in infants with established G3-BPD undergoing their first extubation attempt after 36 weeks PMA, with lower odds of success as RSS increases.