Scholarlink

Objective <p>To investigate the impact of hyperglycemia on the neurodevelopmental outcomes in extremely preterm infants.</p> Study design <p>This single-center retrospective cohort study enrolled extremely preterm infants born at &lt;28 weeks of gestation. Hyperglycemia was defined as a blood glucose level of &gt;15 mmol/L. The Kyoto Scale of Psychological Development at 18 months of corrected age was used for neurodevelopmental assessment, and a developmental quotient (DQ) of ≥85 was defined as normal.</p> Results <p>Among the 102 surviving extremely preterm infants, 54 (53%) had hyperglycemia. The hyperglycemia group had lower DQ (81.0 ± 19.3 vs. 91.1 ± 15.3, <i>P</i> &lt; 0.01) and decreased normal DQ rate (37% vs. 75%, <i>P</i> &lt; 0.001). In the multiple logistic regression models, hyperglycemia was significantly associated with lower normal DQ rates (<i>P</i> = 0.03).</p> Conclusion <p>Hyperglycemia, defined as a blood glucose level of &gt;15 mmol/L, was independently negatively associated with normal DQ after adjusting for confounders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of hyperglycemia in extremely preterm infants with neurodevelopmental outcomes at 18 months of corrected age

  • 期刊论文

  • 发表日期：

    2025年8月18日

查看全文
  • Yohei Minamitani,
  • Kazusa Nakajima,
  • Fumihiko Namba

摘要

Objective

To investigate the impact of hyperglycemia on the neurodevelopmental outcomes in extremely preterm infants.

Study design

This single-center retrospective cohort study enrolled extremely preterm infants born at <28 weeks of gestation. Hyperglycemia was defined as a blood glucose level of >15 mmol/L. The Kyoto Scale of Psychological Development at 18 months of corrected age was used for neurodevelopmental assessment, and a developmental quotient (DQ) of ≥85 was defined as normal.

Results

Among the 102 surviving extremely preterm infants, 54 (53%) had hyperglycemia. The hyperglycemia group had lower DQ (81.0 ± 19.3 vs. 91.1 ± 15.3, P < 0.01) and decreased normal DQ rate (37% vs. 75%, P < 0.001). In the multiple logistic regression models, hyperglycemia was significantly associated with lower normal DQ rates (P = 0.03).

Conclusion

Hyperglycemia, defined as a blood glucose level of >15 mmol/L, was independently negatively associated with normal DQ after adjusting for confounders.