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Objectives <p>To assess risk factors for acute kidney injury (AKI) in neonates with hypoxic ischemic encephalopathy (HIE) using KDIGO and Gupta definitions, and evaluate long-term kidney function.</p> Methods <p>Retrospective study including 72 neonates with HIE and prospective evaluation of long-term kidney health data of 33 survivors.</p> Results <p>AKI was detected in 49% using KDIGO and 32% using Gupta’s definition. KDIGO-defined AKI correlated with thrombocytopenia, low pH, transfusions need, nephrotoxic drugs, and furosemide use (<i>p</i> &lt; 0.05). The Gupta definition showed additional associations with hypotension, cardiac dysfunction, and death (<i>p</i> &lt; 0.05). In a logistic regression model, both definitions linked AKI to nephrotoxic drug exposure and transfusions. Follow-up assessments revealed elevated blood pressure in 12%, hyperfiltration in 18%, and proteinuria in 6% of survivors.</p> Conclusions <p>The Gupta definition may help identify AKI in an additional number of neonates with HIE. Long-term monitoring is essential for the early detection of kidney dysfunction.</p>

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Evaluation of risk factors and outcomes of neonates with hypoxic ischemic encephalopathy and acute kidney injury

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Sara Todo Bom Costa,
  • Patrícia Costa Reis,
  • André Mendes Graça

摘要

Objectives

To assess risk factors for acute kidney injury (AKI) in neonates with hypoxic ischemic encephalopathy (HIE) using KDIGO and Gupta definitions, and evaluate long-term kidney function.

Methods

Retrospective study including 72 neonates with HIE and prospective evaluation of long-term kidney health data of 33 survivors.

Results

AKI was detected in 49% using KDIGO and 32% using Gupta’s definition. KDIGO-defined AKI correlated with thrombocytopenia, low pH, transfusions need, nephrotoxic drugs, and furosemide use (p < 0.05). The Gupta definition showed additional associations with hypotension, cardiac dysfunction, and death (p < 0.05). In a logistic regression model, both definitions linked AKI to nephrotoxic drug exposure and transfusions. Follow-up assessments revealed elevated blood pressure in 12%, hyperfiltration in 18%, and proteinuria in 6% of survivors.

Conclusions

The Gupta definition may help identify AKI in an additional number of neonates with HIE. Long-term monitoring is essential for the early detection of kidney dysfunction.