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Objective <p>To describe the effects of dexmedetomidine on sedation, pain, respiratory status, and hemodynamics in neonates.</p> Methods <p>A retrospective study of 206 infants in a level IV NICU (2016–2021) receiving continuous dexmedetomidine infusion. Pain/sedation scores, BP, vasopressor and inotrope score (VIS), and concomitant sedatives/analgesics (CSA) were recorded before and every 3–4 h for 24 h.</p> Results <p>Median PMA:32 weeks. Hypotension occurred in 26%, primarily in infants &lt;32weeks PMA, correlating with higher VIS and CSA. CSA use significantly predicted vasopressors/inotrope use.</p> Conclusion <p>Dexmedetomidine, with CSA, increases cardiovascular instability in preterm infants who have unique myocardial structure and function and therefore higher vulnerability.</p> Clinical Trial Registration (if any) <p>None (not applicable).</p>

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Dexmedetomidine’s effect on neonatal sedation, pain, respiratory status and cardiovascular system

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Marjorie M. Makoni,
  • Ivonne Sierra-Strum,
  • Adrianne R. Bischoff,
  • Jamie L. Miller,
  • Lise DeShea,
  • William Howard Beasley,
  • Edgardo Szyld

摘要

Objective

To describe the effects of dexmedetomidine on sedation, pain, respiratory status, and hemodynamics in neonates.

Methods

A retrospective study of 206 infants in a level IV NICU (2016–2021) receiving continuous dexmedetomidine infusion. Pain/sedation scores, BP, vasopressor and inotrope score (VIS), and concomitant sedatives/analgesics (CSA) were recorded before and every 3–4 h for 24 h.

Results

Median PMA:32 weeks. Hypotension occurred in 26%, primarily in infants <32weeks PMA, correlating with higher VIS and CSA. CSA use significantly predicted vasopressors/inotrope use.

Conclusion

Dexmedetomidine, with CSA, increases cardiovascular instability in preterm infants who have unique myocardial structure and function and therefore higher vulnerability.

Clinical Trial Registration (if any)

None (not applicable).