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Objective <p>To determine postnatal changes in total serum bilirubin (TB), unbound bilirubin (UB), and bilirubin-binding affinity of albumin (Ka) among Japanese newborns.</p> Study design <p>In a retrospective study, we evaluated for serum TB, UB, and albumin (Alb) levels, and their calculated UB/TB ratios, and Ka in 786 neonates born ≥36 weeks’ gestation and analyzed to subcategories of three postnatal epochs: first, second, and ≥third weeks.</p> Result <p>TB levels were significantly higher (<i>p</i> &lt; 0.01) at age ≥three weeks, while UB levels were significantly higher (<i>p</i> &lt; 0.01) in the first week. UB/TB ratios were significantly lower while calculated Ka values were significantly higher as age-in-weeks increased (<i>p</i> &lt; 0.01).</p> Conclusion <p>Hyperbilirubinemia in the first and second weeks of age in neonates born ≥36 weeks’ gestation is associated with higher UB levels or UB/TB ratios with lower Ka and may potentially contribute to the risk of developing bilirubin neurotoxicity with aggravated variations in bilirubin, albumin and Ka.</p>

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Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates

  • 期刊论文

  • 发表日期：

    2025年3月20日

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  • Kazuki Nishizawa,
  • Yoshinori Katayama,
  • Yong-Kye Lee

摘要

Objective

To determine postnatal changes in total serum bilirubin (TB), unbound bilirubin (UB), and bilirubin-binding affinity of albumin (Ka) among Japanese newborns.

Study design

In a retrospective study, we evaluated for serum TB, UB, and albumin (Alb) levels, and their calculated UB/TB ratios, and Ka in 786 neonates born ≥36 weeks’ gestation and analyzed to subcategories of three postnatal epochs: first, second, and ≥third weeks.

Result

TB levels were significantly higher (p < 0.01) at age ≥three weeks, while UB levels were significantly higher (p < 0.01) in the first week. UB/TB ratios were significantly lower while calculated Ka values were significantly higher as age-in-weeks increased (p < 0.01).

Conclusion

Hyperbilirubinemia in the first and second weeks of age in neonates born ≥36 weeks’ gestation is associated with higher UB levels or UB/TB ratios with lower Ka and may potentially contribute to the risk of developing bilirubin neurotoxicity with aggravated variations in bilirubin, albumin and Ka.