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Objective <p>This study reports on patent ductus arteriosus (PDA) therapy trends across the Children’s Hospital Neonatal Consortium.</p> Study design <p>We performed a 12-year (2011–2022) retrospective study of premature infants (&lt; 33 weeks) with a PDA. We utilized descriptive statistics to compare demographic, inpatient, and discharge characteristics in 3-year epochs.</p> Result <p>From 54,813 infants, 19,843 (36%) had a diagnosis of PDA. Use of pharmacotherapy increased 44% (relative) over time, mostly with increased acetaminophen use. There was a 12.7-fold increase in exposure to multiple PDA medications over the study period. While the rate of definitive closure did not change, use of transcatheter PDA closure increased from 0 to 20.3% and surgical ligation decreased from 25.1% to 3.6%.</p> Conclusion <p>There has been an increase in the use of multiple pharmacotherapies for PDA, especially among infants born &lt;27 weeks’ gestation. Transcatheter PDA closure has overtaken surgical ligation as the primary method of definitive PDA closure.</p>

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Management of the patent ductus arteriosus among infants born at 23 to 32 weeks’ gestation between 2011 to 2022: a report from in the Children’s Hospitals Neonatal Consortium

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月15日

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  • Mark F. Weems,
  • Molly K. Ball,
  • Isabella Zaniletti,
  • Sharifa Habib,
  • Shannon Hamrick,
  • Theresa R. Grover,
  • Sarah Keene,
  • Karna Murthy,
  • Michael Padula,
  • Ranjit Philip,
  • Rakesh Rao,
  • Shawn Sen,
  • Philip T. Levy,
  • Sharada H. Gowda

摘要

Objective

This study reports on patent ductus arteriosus (PDA) therapy trends across the Children’s Hospital Neonatal Consortium.

Study design

We performed a 12-year (2011–2022) retrospective study of premature infants (< 33 weeks) with a PDA. We utilized descriptive statistics to compare demographic, inpatient, and discharge characteristics in 3-year epochs.

Result

From 54,813 infants, 19,843 (36%) had a diagnosis of PDA. Use of pharmacotherapy increased 44% (relative) over time, mostly with increased acetaminophen use. There was a 12.7-fold increase in exposure to multiple PDA medications over the study period. While the rate of definitive closure did not change, use of transcatheter PDA closure increased from 0 to 20.3% and surgical ligation decreased from 25.1% to 3.6%.

Conclusion

There has been an increase in the use of multiple pharmacotherapies for PDA, especially among infants born <27 weeks’ gestation. Transcatheter PDA closure has overtaken surgical ligation as the primary method of definitive PDA closure.