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Objective <p>Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.</p> Study design <p>Patients admitted to the NICU at Tokyo Metropolitan Children’s Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.</p> Results <p>ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.</p> Conclusion <p>Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.</p>

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Extended-spectrum β-lactamase-producing Enterobacterales infections among infants following vertical colonization in a neonatal intensive care unit

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • Mimori Abe,
  • Yuto Otsubo,
  • Tomoyuki Tame,
  • Kaoru Okazaki,
  • Yuho Horikoshi

摘要

Objective

Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.

Study design

Patients admitted to the NICU at Tokyo Metropolitan Children’s Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.

Results

ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.

Conclusion

Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.