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Objective <p>To determine if visuocortical development in premature infants with high bilirubin levels is more adversely affected than that in full-term infants.</p> Study design <p>57 preterm infants were managed using institutional guidelines for hyperbilirubinemia. At 12-months corrected age, Vernier acuity, contrast sensitivity, and grating acuity measured using the sweep visual evoked potential (sVEP) were correlated to total serum/plasma bilirubin (TSB) levels in the first week of life.</p> Result <p>As TSB levels increased, Vernier acuity worsened in infants &lt;34 weeks’ gestation compared with those &gt;34 to &lt;37 weeks’ gestation (<i>p</i> &lt; 0.001). Contrast sensitivity varied as a function of TSB levels (Spearman correlation 0.63, <i>p</i> &lt; 0.001). Grating acuity was unaffected.</p> Conclusion <p>Vernier acuity in preterm infants &lt;34 weeks’ gestation is more vulnerable to the effects of bilirubin, suggesting that the extrastriate visual cortex is primarily affected by bilirubin. Therefore, guidelines for management of hyperbilirubinemia in preterm infants (&lt;34 weeks’ gestation) should be revised.</p>

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Effect of bilirubin on visuocortical development in preterm infants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月5日

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  • William V. Good,
  • Ronald J. Wong,
  • Anthony M. Norcia,
  • Chuan Hou,
  • Jillian Cellucci,
  • Margaret Q. McGovern,
  • Audrey Wong-Kee-You,
  • Gabriela Acevedo Munares,
  • Delene Richburg,
  • Cam Loveridge-easther,
  • Jane S. Lee,
  • Lilia DeJesus,
  • Terri Slagle,
  • David K. Stevenson,
  • Vinod K. Bhutani

摘要

Objective

To determine if visuocortical development in premature infants with high bilirubin levels is more adversely affected than that in full-term infants.

Study design

57 preterm infants were managed using institutional guidelines for hyperbilirubinemia. At 12-months corrected age, Vernier acuity, contrast sensitivity, and grating acuity measured using the sweep visual evoked potential (sVEP) were correlated to total serum/plasma bilirubin (TSB) levels in the first week of life.

Result

As TSB levels increased, Vernier acuity worsened in infants <34 weeks’ gestation compared with those >34 to <37 weeks’ gestation (p < 0.001). Contrast sensitivity varied as a function of TSB levels (Spearman correlation 0.63, p < 0.001). Grating acuity was unaffected.

Conclusion

Vernier acuity in preterm infants <34 weeks’ gestation is more vulnerable to the effects of bilirubin, suggesting that the extrastriate visual cortex is primarily affected by bilirubin. Therefore, guidelines for management of hyperbilirubinemia in preterm infants (<34 weeks’ gestation) should be revised.