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<p>To determine the impact of cumulative systolic blood pressure (cumulative SBP) on increased arterial stiffness in a northern Chinese community. A total of 427 participants from the Kailuan study were enrolled. The median age was 59.0 years (interquartile range 52.0, 66.0). Cumulative SBP was calculated from BP measurements recorded in 2006–2022 by quartile. Logistic regression was used to estimate odds ratios (ORs) and confidence intervals (CIs). The prevalence of increased arterial stiffness at the last follow-up was compared with the predicted risk using the area under the curve, net reclassification index at the event rate, and integrated discrimination index, first with baseline SBP and then with cumulative BP values. Increased arterial stiffness was associated with cumulative SBP in Q4 (OR 2.34, 95% CI 1.25–4.40). The association was more significant in females (OR 3.07, 95% CI 1.16–8.28). The OR was 18.56 (95% CI 2.04–278.80) in patients aged ≤50 years and 2.06 (95% CI 1.03–4.15) in those aged &gt;50 years. Participants with higher cumulative SBP had significantly higher carotid–femoral pulse wave velocity and a greater likelihood of higher arterial stiffness. The prevalence of increased arterial stiffness was 30.8% in Q1, 37.7% in Q2, 49.1% in Q3, and 65.1% in Q4 (p &lt; 0.05). Cumulative SBP resulted in significant improvements in the category-free net reclassification index for all participants (0.25, 95% CI 0.02–0.47) and in females (0.43, 95% CI 0.12–0.75). Long-term high cumulative blood pressure is associated with increased arterial stiffness. Cumulative SBP improved risk reclassification for increased artery stiffness when compared to single SBP.</p>

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Effects of cumulative systolic blood pressure on arterial stiffness: a cross-sectional study based on a community in northern China with 16 years of follow-up

  • 期刊论文

  • 发表日期：

    2026年5月11日

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  • Chen Su,
  • Ying Hui,
  • Xinyu Zhao,
  • Shuohua Chen,
  • Jianjiao Wang,
  • Siyu Wang,
  • Jinyi Han,
  • Mo Zhang,
  • Shouling Wu,
  • Yuntao Wu,
  • LinXue Qian,
  • Xian-Quan Shi

摘要

To determine the impact of cumulative systolic blood pressure (cumulative SBP) on increased arterial stiffness in a northern Chinese community. A total of 427 participants from the Kailuan study were enrolled. The median age was 59.0 years (interquartile range 52.0, 66.0). Cumulative SBP was calculated from BP measurements recorded in 2006–2022 by quartile. Logistic regression was used to estimate odds ratios (ORs) and confidence intervals (CIs). The prevalence of increased arterial stiffness at the last follow-up was compared with the predicted risk using the area under the curve, net reclassification index at the event rate, and integrated discrimination index, first with baseline SBP and then with cumulative BP values. Increased arterial stiffness was associated with cumulative SBP in Q4 (OR 2.34, 95% CI 1.25–4.40). The association was more significant in females (OR 3.07, 95% CI 1.16–8.28). The OR was 18.56 (95% CI 2.04–278.80) in patients aged ≤50 years and 2.06 (95% CI 1.03–4.15) in those aged >50 years. Participants with higher cumulative SBP had significantly higher carotid–femoral pulse wave velocity and a greater likelihood of higher arterial stiffness. The prevalence of increased arterial stiffness was 30.8% in Q1, 37.7% in Q2, 49.1% in Q3, and 65.1% in Q4 (p < 0.05). Cumulative SBP resulted in significant improvements in the category-free net reclassification index for all participants (0.25, 95% CI 0.02–0.47) and in females (0.43, 95% CI 0.12–0.75). Long-term high cumulative blood pressure is associated with increased arterial stiffness. Cumulative SBP improved risk reclassification for increased artery stiffness when compared to single SBP.