Scholarlink

<p>Continuous Positive Airway Pressure (CPAP) is the gold standard treatment for Obstructive Sleep Apnea (OSA). Its long-term effects on Resistant Hypertension (RHT) have not yet been fully established. We conducted a prospective intervention study to evaluate the impact of long-term CPAP therapy on office and ambulatory blood pressure (BP) in patients with RHT and moderate to severe OSA. Patients who used CPAP for a minimum of 12 months were included in the CPAP group and compared with those who declined to use CPAP despite clinical indications (control group). All participants underwent 24-h ambulatory blood pressure monitoring (ABPM) at baseline and at the end of the study. Intergroup comparisons of BP changes were performed using a general linear model, including two per-protocol analyses for patients with optimal CPAP adherence (at least 4 h/night) and those with refractory hypertension. A total of 124 individuals were included (65 in the CPAP group and 59 controls), with a mean age of 60.7 ± 7.8 years. The intention-to-treat analysis found no significant differences in overall BP changes between groups. The per-protocol analyses (50 CPAP users with optimal adherence and 28 with refractory hypertension) showed significant reductions in nighttime systolic BP (−8.1 mmHg (95% CI −14.7 to −1.5) and −25.6 mmHg (95% CI −40.1 – −10.5), respectively) and in nighttime diastolic BP (−5.3 mmHg (95% CI −9.6 to −1.1) and −13.9 mmHg (95% CI −22.5 – −5.3), respectively). These findings suggest that while CPAP benefits adherent patients and refractory hypertensives, its overall long-term effects on resistant hypertension require further investigation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea

  • 期刊论文

  • 发表日期：

    2025年5月28日

查看全文
  • Ana Cristina Tenório da Costa Fernandes,
  • João Carlos Moreno Azevedo,
  • Elizabeth Silaid Muxfeldt,
  • Fabio de Souza

摘要

Continuous Positive Airway Pressure (CPAP) is the gold standard treatment for Obstructive Sleep Apnea (OSA). Its long-term effects on Resistant Hypertension (RHT) have not yet been fully established. We conducted a prospective intervention study to evaluate the impact of long-term CPAP therapy on office and ambulatory blood pressure (BP) in patients with RHT and moderate to severe OSA. Patients who used CPAP for a minimum of 12 months were included in the CPAP group and compared with those who declined to use CPAP despite clinical indications (control group). All participants underwent 24-h ambulatory blood pressure monitoring (ABPM) at baseline and at the end of the study. Intergroup comparisons of BP changes were performed using a general linear model, including two per-protocol analyses for patients with optimal CPAP adherence (at least 4 h/night) and those with refractory hypertension. A total of 124 individuals were included (65 in the CPAP group and 59 controls), with a mean age of 60.7 ± 7.8 years. The intention-to-treat analysis found no significant differences in overall BP changes between groups. The per-protocol analyses (50 CPAP users with optimal adherence and 28 with refractory hypertension) showed significant reductions in nighttime systolic BP (−8.1 mmHg (95% CI −14.7 to −1.5) and −25.6 mmHg (95% CI −40.1 – −10.5), respectively) and in nighttime diastolic BP (−5.3 mmHg (95% CI −9.6 to −1.1) and −13.9 mmHg (95% CI −22.5 – −5.3), respectively). These findings suggest that while CPAP benefits adherent patients and refractory hypertensives, its overall long-term effects on resistant hypertension require further investigation.