Background <p>Indoor building materials and household chemical products are suspected to contribute to the development of childhood asthma and allergy. Studies focusing on household chemical products and childhood allergies in China have been limited. Moreover, the mutual associations of indoor building materials and household chemical products on childhood asthma and allergies remain unclear.</p> Objective <p>The aim of this study is to investigate the associations between current asthma and allergic symptoms in Chinese children and the use of indoor building materials and household chemical products. Additionally, we aim to explore the mutual associations of indoor building materials and household chemical products in Chinese homes on children’s current asthma and allergic symptoms.</p> Methods <p>Logistic regression models, including one-exposure and mutual-adjustment models were employed to investigate the association of childhood asthma and allergies with indoor building materials and household chemical products.</p> Results <p>Indoor building materials and household chemical products were found to be associated with asthma and allergic symptoms in children. Specifically, significant associations were observed between laminated wood flooring and current rhinitis (Adjusted odds ratio (AOR): 1.70), PVC-framed windows and current rhinitis (AOR: 2.33), as well as hair care products and current eczema (AOR: 2.04). Additionally, a significant dose-response relationship was identified between the cumulative usage number of cosmetics and current wheeze in children (<i>p</i> for trend = 0.03).</p> Significance <p>Our findings underscore the significance of choosing safer household consumer products (such as indoor building materials, cosmetics, and hair care products) in managing asthma and allergies among children.</p> Impact <p>Exposure to indoor building materials and household chemical products in homes, especially laminated wood flooring, PVC-framed windows, hair care products and cosmetics, may be a risk factor for current asthma and allergic symptoms in children, even if children are not direct users of certain household chemical products.</p>