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<p>The purpose of this study was to investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiac function and myocardial work (MW) in women with obesity. Twenty-five women with obesity (Age: 28 ± 5 years, BMI: 35.03 ± 3.19 kg/m²) were randomized to 8 weeks of either HIIT (<i>n</i> = 11, 4×4-min at 85–95% of HR<sub>max</sub>) or MICT (<i>n</i> = 14, 41-min at 65–75% of HR<sub>max</sub>). Cardiac function and strains were evaluated using two-dimensional speckle tracking echocardiography. MW indices were computed via dedicated software. HIIT significantly improved myocardial efficiency, as evidenced by a reduction in global wasted work (GWW [<i>d</i> = 0.64, <i>p</i> = 0.042]) and an increase global work efficiency (GWE [<i>d</i> = 0.83, <i>p</i> = 0.005]). Both HIIT and MICT reduced left ventricular global longitudinal strain (GLS, <i>p</i> = 0.017 for HIIT; <i>p</i> = 0.023 for MICT), left atrial (LA) contraction (<i>p</i> &lt; 0.001 for both), LA conduit (p = 0.002 for both), LA reservoir (<i>p</i> = 0.003 for HIIT; <i>p</i> &lt; 0.001 for MICT), and LA stiffness (<i>p</i> = 0.004 for HIIT, <i>p</i> = 0.031 for MICT). HIIT and MICT both improved myocardial deformation in women with obesity. However, only HIIT improved myocardial efficiency, suggesting a potential superiority for targeting subclinical cardiac dysfunction in this population.</p><p></p>

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High-intensity interval training improves myocardial work and cardiac function in women with obesity: a randomized controlled study

  • 期刊论文

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  • 发表日期：

    2026年7月10日

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  • Caroline Ferraz Simões,
  • Higor Barbosa Reck,
  • João Carlos Locatelli,
  • Gustavo Henrique de Oliveira,
  • Victor Hugo de Souza Mendes,
  • Rogério Toshiro Passos Okawa,
  • Jamie O’Driscoll,
  • Jorge Mota,
  • Wendell Arthur Lopes

摘要

The purpose of this study was to investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiac function and myocardial work (MW) in women with obesity. Twenty-five women with obesity (Age: 28 ± 5 years, BMI: 35.03 ± 3.19 kg/m²) were randomized to 8 weeks of either HIIT (n = 11, 4×4-min at 85–95% of HRmax) or MICT (n = 14, 41-min at 65–75% of HRmax). Cardiac function and strains were evaluated using two-dimensional speckle tracking echocardiography. MW indices were computed via dedicated software. HIIT significantly improved myocardial efficiency, as evidenced by a reduction in global wasted work (GWW [d = 0.64, p = 0.042]) and an increase global work efficiency (GWE [d = 0.83, p = 0.005]). Both HIIT and MICT reduced left ventricular global longitudinal strain (GLS, p = 0.017 for HIIT; p = 0.023 for MICT), left atrial (LA) contraction (p < 0.001 for both), LA conduit (p = 0.002 for both), LA reservoir (p = 0.003 for HIIT; p < 0.001 for MICT), and LA stiffness (p = 0.004 for HIIT, p = 0.031 for MICT). HIIT and MICT both improved myocardial deformation in women with obesity. However, only HIIT improved myocardial efficiency, suggesting a potential superiority for targeting subclinical cardiac dysfunction in this population.