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Objective <p>Given the potential of organochlorine pesticides (OCPs) to disrupt metabolic health, we aimed to explore their association with obesity and to explore the potential bidirectional mediating relationships involving metabolic health indicators among 894 rural Chinese adults with prediabetes.</p> Methods <p>A total of 894 individuals were included in this cross-sectional study. The associations of plasma OCPs on obesity and obese anthropometric measurements were assessed by generalized linear regression models for single exposure, and quantile g-computation (QGC) and LASSO regression for mixed exposure. The potential contributions of multiple health indicators to observed associations were assessed through mediation analysis. Exploratory bidirectional mediation analysis was employed to assess two potential pathways: (1) whether metabolic health indicators mediate the association between OCP exposure and obesity, and (2) whether obesity mediates the relationship between OCP exposure and metabolic health indicators.</p> Results <p>We discovered that β-Benzene hexachloride (β-BHC) and p,p’-Dichlorodiphenyldichloroethylene (p,p’-DDE) were related to obesity for single exposure. QGC and LASSO demonstrated that OCPs were positively correlated with a higher likelihood of obesity for mixed exposure, with β-BHC being the primary contributor. Exploratory mediation analysis found that obesity and metabolic-related indicators play a bidirectional mediating role in the association with OCPs, mainly involving systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-Cholesterol (HDL-C), low-density lipoprotein-Cholesterol (LDL-C), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase/alanine aminotransferase (AST/ALT).</p> Conclusions <p>In this cross-sectional study, we found that OCPs exposure may increase obesity risk both directly and by disrupting metabolism, while obesity itself can worsen OCP-related metabolic damage, revealing a bidirectional environment-body interaction.</p> <p></p>

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Organochlorine pesticides and obesity in a rural prediabetic population: exploring bidirectional pathways with metabolic indicators

  • 期刊论文

  • 发表日期：

    2026年2月27日

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  • Jiayu Shi,
  • Dandan Wei,
  • Cuicui Ma,
  • Jintian Geng,
  • Mengzhen Zhao,
  • Jian Hou,
  • Wenqian Huo,
  • Tao Jing,
  • Zhuo Chen,
  • Shan Huang,
  • Xin Zeng,
  • Chongjian Wang,
  • Zhenxing Mao

摘要

Objective

Given the potential of organochlorine pesticides (OCPs) to disrupt metabolic health, we aimed to explore their association with obesity and to explore the potential bidirectional mediating relationships involving metabolic health indicators among 894 rural Chinese adults with prediabetes.

Methods

A total of 894 individuals were included in this cross-sectional study. The associations of plasma OCPs on obesity and obese anthropometric measurements were assessed by generalized linear regression models for single exposure, and quantile g-computation (QGC) and LASSO regression for mixed exposure. The potential contributions of multiple health indicators to observed associations were assessed through mediation analysis. Exploratory bidirectional mediation analysis was employed to assess two potential pathways: (1) whether metabolic health indicators mediate the association between OCP exposure and obesity, and (2) whether obesity mediates the relationship between OCP exposure and metabolic health indicators.

Results

We discovered that β-Benzene hexachloride (β-BHC) and p,p’-Dichlorodiphenyldichloroethylene (p,p’-DDE) were related to obesity for single exposure. QGC and LASSO demonstrated that OCPs were positively correlated with a higher likelihood of obesity for mixed exposure, with β-BHC being the primary contributor. Exploratory mediation analysis found that obesity and metabolic-related indicators play a bidirectional mediating role in the association with OCPs, mainly involving systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein-Cholesterol (HDL-C), low-density lipoprotein-Cholesterol (LDL-C), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase/alanine aminotransferase (AST/ALT).

Conclusions

In this cross-sectional study, we found that OCPs exposure may increase obesity risk both directly and by disrupting metabolism, while obesity itself can worsen OCP-related metabolic damage, revealing a bidirectional environment-body interaction.