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Background <p>Circulating S100 β and neuron-specific enolase (NSE) have been used to explore brain damage in adults with obesity. Nonetheless, the subtle increase of these molecules can be found in non-pathological conditions in healthy subjects, indicating possible disturbances in brain function.</p> Objective <p>We aimed to compare serum levels of S100β and NSE between children with and without obesity.</p> Subjects and methods <p>We analyzed circulating S100β and NSE and performed correlations with anthropometry and biochemical parameters from 80 children between 6 and 11 years old, divided into two groups: children with obesity (Body mass index ≥97th percentile) and children with normal body weight (between the 5th and 85th percentile).</p> Results <p>Our results show that children with obesity have approximately 50% more circulating levels of S100β and NSE. Furthermore, we found a positive correlation between S100β and circulating resistin and a positive correlation between NSE and Body mass index, waist circumference, and waist-to-hip ratio. Conversely, NSE and adiponectin showed a negative correlation.</p> Conclusion <p>S100β and NSE levels in blood were associated with indicators of metabolic impairment. Future studies are needed to determine if the increase of S100β and NSE in children with obesity is related to cognitive function.</p> <p></p>

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Serum S100β and neuron-specific enolase correlate with obesity parameters in Mexican children

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月24日

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  • Gabriela Hurtado-Alvarado,
  • Rebeca Mendez-Hernandez,
  • Karol Iliana Avila-Soto,
  • Alberto Salazar-Juárez,
  • Mónica Espinoza-Rojo,
  • Carolina Escobar,
  • Miguel Vázquez-Moreno,
  • Miguel Cruz

摘要

Background

Circulating S100 β and neuron-specific enolase (NSE) have been used to explore brain damage in adults with obesity. Nonetheless, the subtle increase of these molecules can be found in non-pathological conditions in healthy subjects, indicating possible disturbances in brain function.

Objective

We aimed to compare serum levels of S100β and NSE between children with and without obesity.

Subjects and methods

We analyzed circulating S100β and NSE and performed correlations with anthropometry and biochemical parameters from 80 children between 6 and 11 years old, divided into two groups: children with obesity (Body mass index ≥97th percentile) and children with normal body weight (between the 5th and 85th percentile).

Results

Our results show that children with obesity have approximately 50% more circulating levels of S100β and NSE. Furthermore, we found a positive correlation between S100β and circulating resistin and a positive correlation between NSE and Body mass index, waist circumference, and waist-to-hip ratio. Conversely, NSE and adiponectin showed a negative correlation.

Conclusion

S100β and NSE levels in blood were associated with indicators of metabolic impairment. Future studies are needed to determine if the increase of S100β and NSE in children with obesity is related to cognitive function.