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Background <p>Dynapenic abdominal obesity (D/AO) is defined as the combination of decreased handgrip strength and high waist circumference. It is necessary to explore its combined effect on long-term changes in cognitive function to identify those who could benefit most from neurocognitive preventive strategies.</p> Methods <p>Longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS, 2015–2020) was used, including 6698 individuals aged 45 years and over. Participants were divided into nondynapenic nonabdominal obesity (ND/NAO), nondynapenic abdominal obesity (ND/AO), dynapenic nonabdominal obesity (D/NAO), and D/AO, based on the sex-specific grip strength and waist circumference. Group-based trajectory modeling (GBTM) was adopted to identify the potential heterogeneity of longitudinal changes over the past 6 years, and logistic regression was used to explore the association of baseline D/AO with trajectories of cognitive function and the occurrence of mild cognitive impairment (MCI).</p> Results <p>Three trajectories were identified in results: lower cognition group, moderate cognition group and higher cognition group. D/NAO and D/AO were associated with the lower cognition (D/NAO: OR = 1.51, 95% CI: 1.01-2.27; D/AO: OR = 1.90, 95% CI: 1.19–3.04). Participants in D/NAO and D/AO had a higher risk of changing from healthy to MCI (D/NAO: OR = 1.52, 95% CI: 1.06–2.19; D/AO: OR = 1.61, 95% CI: 1.07–2.42).</p> Conclusion <p>D/AO is associated with long-term lower cognition and MCI in middle-aged and older patients, making it a potentially valuable tool for early intervention in dementia prevention.</p>

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Dynapenic abdominal obesity is associated with long-term cognitive trajectories and mild cognitive impairment

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Shuai Zhu,
  • Xiaohui Li,
  • Bosen Lv,
  • Yan Wu,
  • Bixuan Liu,
  • Liying Jing,
  • Jingyi Wang,
  • Weijing Wang,
  • Yanping Sun,
  • Yili Wu

摘要

Background

Dynapenic abdominal obesity (D/AO) is defined as the combination of decreased handgrip strength and high waist circumference. It is necessary to explore its combined effect on long-term changes in cognitive function to identify those who could benefit most from neurocognitive preventive strategies.

Methods

Longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS, 2015–2020) was used, including 6698 individuals aged 45 years and over. Participants were divided into nondynapenic nonabdominal obesity (ND/NAO), nondynapenic abdominal obesity (ND/AO), dynapenic nonabdominal obesity (D/NAO), and D/AO, based on the sex-specific grip strength and waist circumference. Group-based trajectory modeling (GBTM) was adopted to identify the potential heterogeneity of longitudinal changes over the past 6 years, and logistic regression was used to explore the association of baseline D/AO with trajectories of cognitive function and the occurrence of mild cognitive impairment (MCI).

Results

Three trajectories were identified in results: lower cognition group, moderate cognition group and higher cognition group. D/NAO and D/AO were associated with the lower cognition (D/NAO: OR = 1.51, 95% CI: 1.01-2.27; D/AO: OR = 1.90, 95% CI: 1.19–3.04). Participants in D/NAO and D/AO had a higher risk of changing from healthy to MCI (D/NAO: OR = 1.52, 95% CI: 1.06–2.19; D/AO: OR = 1.61, 95% CI: 1.07–2.42).

Conclusion

D/AO is associated with long-term lower cognition and MCI in middle-aged and older patients, making it a potentially valuable tool for early intervention in dementia prevention.