Scholarlink

Background/objectives <p>We provide the rationale for and description of energy balance measures (i.e., energy intake and energy expenditure) in The <Emphasis Type="Underline">P</Emphasis>hysiology <Emphasis Type="Underline">O</Emphasis>f the <Emphasis Type="Underline">WE</Emphasis>ight <Emphasis Type="Underline">R</Emphasis>educed <Emphasis Type="Underline">S</Emphasis>tate (POWERS) study which aims to understand the contribution of the many factors that influence weight regain following behavioral weight loss.</p> Methods <p>The primary dependent variable is weight regain over 1 year following a 7% or greater supervised weight loss. The balance between energy intake and expenditure is the primary determinant of weight regain. Healthy adults (target <i>n</i> = 205), aged 25- &lt; 60 years, with body mass index (BMI) 30- &lt; 40 kg/m<sup>2</sup> are being recruited. Energy intake and expenditure phenotypes are measured prior to weight loss (baseline, BL), immediately following weight loss (T0), and then four (T4) and 12 months (T12) after weight loss. Weight stability is required before BL and T0 measurement periods. Weight change at T12 from T0 is the primary outcome variable. Energy intake is measured with serial doubly labeled water (DLW) measurements combined with dual x-ray absorptiometry (DXA) to assess changes in fat and lean mass; DLW is also used to measure twenty-four-hour energy expenditure (TEE). Components of TEE including resting energy expenditure (REE) and non-resting and activity energy expenditure (NREE and AEE), as well as skeletal muscle chemomechanical efficiency and grip strength are assessed. Self-reported dietary intake is assessed with interviewer-administered multiple-pass 24-hour food recalls.</p> Discussion <p>This manuscript describes the rationale for the methods chosen to assess energy balance and the analytical methods employed to normalize and express data in the setting of changes in body weight and composition immediately following behavioral weight loss and thereafter at 4- and 12-months post-weight loss.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Physiology Of the WEight Reduced State (POWERS) study: assessing energy balance

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月17日

查看全文
  • Michael Rosenbaum,
  • Kelly C. Allison,
  • Maren R. Laughlin,
  • Kathryn Whyte,
  • John M. Jakicic,
  • Laurel E. S. Mayer,
  • Maxine Ashby-Thompson,
  • Matthew R. Hayes,
  • John Speakman,
  • Rudolph L. Leibel,
  • Sai Krupa Das,
  • Dympna Gallagher,
  • Susan B. Roberts,
  • Dympna Gallagher,
  • Rudolph Leibel,
  • Laurel Mayer,
  • Michael Rosenbaum,
  • Maxine Ashby-Thompson,
  • Giada Benasi,
  • Karin Foerde,
  • Rochelle Goldsmith,
  • Michio Hirano,
  • Charles LeDuc,
  • Christina Roberto,
  • Heather Seid,
  • Marie-Pierre St-Onge,
  • Kathryn Whyte,
  • Yiying Zhang,
  • Alexis O. Aparicio,
  • Daaimah Dratsky,
  • Jingrui Gu,
  • Michelle Horowitz,
  • Susan Xiaoqin Lin,
  • Arden McMath,
  • Cynthia Mikula,
  • Joel Matos Nunez,
  • Martin Picard,
  • Janet Schebendach,
  • Yifei Sun,
  • Agnes Wong,
  • Wen Wen Yu,
  • Bret Goodpaster,
  • Susan B. Roberts,
  • Michael Lowe,
  • Alexis Gomez,
  • Sophie Meierovich,
  • Rachel Saks,
  • Mars Scharf,
  • Edward Williams,
  • Anna Zhou,
  • Olive Zhu,
  • Kelly C. Allison,
  • Matthew R. Hayes,
  • Michael Rickels,
  • David Roalf,
  • Gary Wu,
  • Payman Zamani,
  • Lillian Chau,
  • Adam Czernuszenko,
  • Cassandra Demastus,
  • Melissa Fernando,
  • Kubarah Ghias,
  • Gabrielle Grosso,
  • Lindsay Herman,
  • Nathaniel Holmes,
  • Christina Mastracchio,
  • Varsha Sayana,
  • Nicholas Wellman,
  • Sai Krupa Das,
  • Roger Fielding,
  • Andrew Howland,
  • Kyle Burger,
  • John Speakman,
  • Catherine Hambly,
  • Steven H. Belle,
  • Wendy C. King,
  • David Hallam,
  • Tamara Haller,
  • Stephanie S. Kelley,
  • Christopher E. Kline,
  • Kelsey R. Leonard,
  • Andrew J. Pelesko,
  • Matthew Zourelias,
  • Panayiotis V. Benos,
  • John M. Jakicic,
  • Abdus S. Wahed,
  • Kirk I. Erickson,
  • Maren R. Laughlin,
  • Susan Yanovski,
  • Bramaramba Kowtha,
  • Deborah Young-Hyman

摘要

Background/objectives

We provide the rationale for and description of energy balance measures (i.e., energy intake and energy expenditure) in The Physiology Of the WEight Reduced State (POWERS) study which aims to understand the contribution of the many factors that influence weight regain following behavioral weight loss.

Methods

The primary dependent variable is weight regain over 1 year following a 7% or greater supervised weight loss. The balance between energy intake and expenditure is the primary determinant of weight regain. Healthy adults (target n = 205), aged 25- < 60 years, with body mass index (BMI) 30- < 40 kg/m2 are being recruited. Energy intake and expenditure phenotypes are measured prior to weight loss (baseline, BL), immediately following weight loss (T0), and then four (T4) and 12 months (T12) after weight loss. Weight stability is required before BL and T0 measurement periods. Weight change at T12 from T0 is the primary outcome variable. Energy intake is measured with serial doubly labeled water (DLW) measurements combined with dual x-ray absorptiometry (DXA) to assess changes in fat and lean mass; DLW is also used to measure twenty-four-hour energy expenditure (TEE). Components of TEE including resting energy expenditure (REE) and non-resting and activity energy expenditure (NREE and AEE), as well as skeletal muscle chemomechanical efficiency and grip strength are assessed. Self-reported dietary intake is assessed with interviewer-administered multiple-pass 24-hour food recalls.

Discussion

This manuscript describes the rationale for the methods chosen to assess energy balance and the analytical methods employed to normalize and express data in the setting of changes in body weight and composition immediately following behavioral weight loss and thereafter at 4- and 12-months post-weight loss.