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<p>Intentional weight loss is often followed by unintentional weight regain. The causes of weight regain are uncertain but may include a myriad of responses that result in increased hunger and decreased energy expenditure. An individual’s psychological state and social and physical environments are also thought to influence weight regain in ways that can either support or derail weight loss maintenance. Funded by the National Institutes of Health, the Physiology of the WEight Reduced State (POWERS) study is a multi-center clinical trial aimed at describing the molecular, cellular, physiological, behavioral, environmental and psychosocial factors that may be associated with an individual’s ability to maintain their new weight after weight loss. This report provides the rationale for and describes the environmental, psychological and social determinants of health measures used in the POWERS study.</p>

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The Physiology of the WEight-Reduced State (POWERS) study: environmental, psychological, and social determinants of health

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月25日

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  • Sai Krupa Das,
  • Giada Benasi,
  • John M. Jakicic,
  • Wendy C. King,
  • Susan Z. Yanovski,
  • Stephanie S. Kelley,
  • Laurel E. S. Mayer,
  • Kathryn J. Whyte,
  • Michael R. Lowe,
  • Susan B. Roberts,
  • Maren R. Laughlin,
  • Dympna Gallagher,
  • Rudolph Leibel,
  • Laurel Mayer,
  • Michael Rosenbaum,
  • Maxine Ashby-Thompson,
  • Giada Benasi,
  • Karin Foerde,
  • Rochelle Goldsmith,
  • Michio Hirano,
  • Charles LeDuc,
  • Christina Roberto,
  • Heather Seid,
  • Marie-Pierre St-Onge,
  • Kathryn Whyte,
  • Yiying Zhang,
  • Alexis O. Aparicio,
  • Daaimah Dratsky,
  • Jingrui Gu,
  • Michelle Horowitz,
  • Susan Xiaoqin Lin,
  • Arden McMath,
  • Cynthia Mikula,
  • Joel Matos Nunez,
  • Martin Picard,
  • Janet Schebendach,
  • Yifei Sun,
  • Agnes Wong,
  • Wen Wen Yu,
  • Bret Goodpaster,
  • Susan B. Roberts,
  • Michael Lowe,
  • Alexis Gomez,
  • Sophie Meierovich,
  • Rachel Saks,
  • Mars Scharf,
  • Edward Williams,
  • Anna Zhou,
  • Olive Zhu,
  • Kelly C. Allison,
  • Matthew R. Hayes,
  • Michael Rickels,
  • David Roalf,
  • Gary Wu,
  • Payman Zamani,
  • Lillian Chau,
  • Adam Czernuszenko,
  • Cassandra Demastus,
  • Melissa Fernando,
  • Kubarah Ghias,
  • Gabrielle Grosso,
  • Lindsay Herman,
  • Nathaniel Holmes,
  • Christina Mastracchio,
  • Varsha Sayana,
  • Nicholas Wellman,
  • Sai Krupa Das,
  • Roger Fielding,
  • Andrew Howland,
  • Kyle Burger,
  • John Speakman,
  • Catherine Hambly,
  • Steven H. Belle,
  • Wendy C. King,
  • David Hallam,
  • Tamara Haller,
  • Stephanie S. Kelley,
  • Christopher E. Kline,
  • Kelsey R. Leonard,
  • Andrew J. Pelesko,
  • Matthew Zourelias,
  • Panayiotis V. Benos,
  • John M. Jakicic,
  • Abdus S. Wahed,
  • Kirk I. Erickson,
  • Maren R. Laughlin,
  • Yanovski,
  • Bramaramba Kowtha,
  • Deborah Young-Hyman

摘要

Intentional weight loss is often followed by unintentional weight regain. The causes of weight regain are uncertain but may include a myriad of responses that result in increased hunger and decreased energy expenditure. An individual’s psychological state and social and physical environments are also thought to influence weight regain in ways that can either support or derail weight loss maintenance. Funded by the National Institutes of Health, the Physiology of the WEight Reduced State (POWERS) study is a multi-center clinical trial aimed at describing the molecular, cellular, physiological, behavioral, environmental and psychosocial factors that may be associated with an individual’s ability to maintain their new weight after weight loss. This report provides the rationale for and describes the environmental, psychological and social determinants of health measures used in the POWERS study.