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Objective <p>Characterize the effects of obesity on common marmoset glucose metabolism and develop predictive markers of glucose metabolism dysfunction.</p> Methods <p>Body size, weight, lean mass, fat mass, %fat, resting energy expenditure (REE), and glycosylated hemoglobin (HbA1c) were measured on 51 adult marmosets. Physical activity was assessed using actimeter collars (<i>n</i> = 50). A body mass-per-length parameter (BML) was constructed. Animals were classified as without obesity or with obesity (%fat &gt;10%) and by the age they obtained maximum weight (Maxwt). Correlation, MANOVA, and binary logistic regression were used to examine relationships between parameters; path analysis to explore directional relationships.</p> Results <p>Body fat and BML were correlated (<i>r</i> = 0.565, <i>p</i> &lt; 0.001). Both were correlated with HbA1c (<i>r</i> = 0.658; <i>r</i> = 0.764, <i>p</i> &lt; 0.001). Activity was negatively correlated with %fat and REE (<i>r</i> = −0.437, <i>p</i> = 0.002; <i>r</i> = −0.473, <i>p</i> &lt; 0.001). REE was correlated with %fat, BML, and HbA1c (<i>r</i> &gt; 0.5, <i>p</i> &lt; 0.001). Marmosets with obesity were more likely to have elevated HbA1c (&gt;5.7%; odds ratio = 8.25, <i>p</i> = 0.003). BML above 3.4 g/mm predicted obesity (OR = 6.25 [95% CI 1.62–24.02], <i>p</i> = 0.008) and high HbA1c (OR = 29.47 [95% CI 6.21–139.72], <i>p</i> &lt; 0.001). Early Maxwt predicted increased fat mass (<i>F</i> = −0.476, <i>p</i> = 0.015) and high %fat (<i>F</i> = −0.084, <i>p</i> = 0.014).</p> Conclusion <p>Both %fat and BML were markers for high HbA1c. Early maximum adult weight predicts increased adiposity and risk of glucose dysfunction.</p>

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Predictive markers of obesity and glucose metabolism dysfunction in adult common marmosets (Callithrix jacchus)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月25日

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  • Juan Pablo Arroyo,
  • Corinna N. Ross,
  • Jessica Greig,
  • Ricki J. Colman,
  • Suzette D. Tardif,
  • Michael L. Power

摘要

Objective

Characterize the effects of obesity on common marmoset glucose metabolism and develop predictive markers of glucose metabolism dysfunction.

Methods

Body size, weight, lean mass, fat mass, %fat, resting energy expenditure (REE), and glycosylated hemoglobin (HbA1c) were measured on 51 adult marmosets. Physical activity was assessed using actimeter collars (n = 50). A body mass-per-length parameter (BML) was constructed. Animals were classified as without obesity or with obesity (%fat >10%) and by the age they obtained maximum weight (Maxwt). Correlation, MANOVA, and binary logistic regression were used to examine relationships between parameters; path analysis to explore directional relationships.

Results

Body fat and BML were correlated (r = 0.565, p < 0.001). Both were correlated with HbA1c (r = 0.658; r = 0.764, p < 0.001). Activity was negatively correlated with %fat and REE (r = −0.437, p = 0.002; r = −0.473, p < 0.001). REE was correlated with %fat, BML, and HbA1c (r > 0.5, p < 0.001). Marmosets with obesity were more likely to have elevated HbA1c (>5.7%; odds ratio = 8.25, p = 0.003). BML above 3.4 g/mm predicted obesity (OR = 6.25 [95% CI 1.62–24.02], p = 0.008) and high HbA1c (OR = 29.47 [95% CI 6.21–139.72], p < 0.001). Early Maxwt predicted increased fat mass (F = −0.476, p = 0.015) and high %fat (F = −0.084, p = 0.014).

Conclusion

Both %fat and BML were markers for high HbA1c. Early maximum adult weight predicts increased adiposity and risk of glucose dysfunction.