Scholarlink

Background and Importance <p>Photodynamic therapy (PDT) is a promising intraoperative adjunct in the surgical management of glioblastoma (GBM), targeting infiltrative tumor cells beyond visible resection margins. While 5-aminolevulinic acid (5-ALA) is FDA-approved for fluorescence-guided surgery (FGS) in high-grade gliomas (HGGs), its application in intraoperative PDT is under clinical investigation. We report the first use of a new 5-ALA drug-device combination, Pentalafen®-Heliance® Solution, for both FGS and intraoperative PDT in a GBM patient, as part of a Phase I/II clinical study.</p> Clinical Presentation <p>A 64-year-old woman presented with progressive headaches, visual field deficits, and cognitive symptoms. MRI revealed a heterogeneously enhancing right temporo-occipital lesion with vasogenic edema and midline shift, consistent with HGG. She was enrolled in a clinical trial evaluating PDT using the Pentalafen®-Heliance® platform. Oral Pentalafen® was administered 4&#xa0;h prior to surgery. A voice-controlled robotic-assisted exoscope was used for FGS and gross total resection. Intraoperative PDT was then delivered through an inflatable balloon diffuser (Heliance®) positioned in the resection cavity, ensuring homogeneous light distribution. Postoperative MRI confirmed complete resection with no edema or complications. She was discharged on postoperative day 2 and began chemoradiotherapy at week 3. At 3-month follow-up, she remained neurologically stable with no radiographic recurrence.</p> Conclusion <p>This case demonstrates the technical feasibility and safety of integrating 5-ALA-based intraoperative PDT into standard GBM surgery. The combination of modern visualization platforms, advanced optical delivery, and a next-generation photosensitizer supports further clinical investigation of PDT in neuro-oncologic workflows.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fluorescence-guided surgery and intraoperative photodynamic therapy for the treatment of glioblastoma: a technical case report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月5日

查看全文
  • Jheremy S. Reyes,
  • Timoteo Almeida,
  • Alexandros Bouras,
  • Kristy Boggs,
  • Jan Drappatz,
  • Constantinos G. Hadjipanayis

摘要

Background and Importance

Photodynamic therapy (PDT) is a promising intraoperative adjunct in the surgical management of glioblastoma (GBM), targeting infiltrative tumor cells beyond visible resection margins. While 5-aminolevulinic acid (5-ALA) is FDA-approved for fluorescence-guided surgery (FGS) in high-grade gliomas (HGGs), its application in intraoperative PDT is under clinical investigation. We report the first use of a new 5-ALA drug-device combination, Pentalafen®-Heliance® Solution, for both FGS and intraoperative PDT in a GBM patient, as part of a Phase I/II clinical study.

Clinical Presentation

A 64-year-old woman presented with progressive headaches, visual field deficits, and cognitive symptoms. MRI revealed a heterogeneously enhancing right temporo-occipital lesion with vasogenic edema and midline shift, consistent with HGG. She was enrolled in a clinical trial evaluating PDT using the Pentalafen®-Heliance® platform. Oral Pentalafen® was administered 4 h prior to surgery. A voice-controlled robotic-assisted exoscope was used for FGS and gross total resection. Intraoperative PDT was then delivered through an inflatable balloon diffuser (Heliance®) positioned in the resection cavity, ensuring homogeneous light distribution. Postoperative MRI confirmed complete resection with no edema or complications. She was discharged on postoperative day 2 and began chemoradiotherapy at week 3. At 3-month follow-up, she remained neurologically stable with no radiographic recurrence.

Conclusion

This case demonstrates the technical feasibility and safety of integrating 5-ALA-based intraoperative PDT into standard GBM surgery. The combination of modern visualization platforms, advanced optical delivery, and a next-generation photosensitizer supports further clinical investigation of PDT in neuro-oncologic workflows.