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<p>In this work, lycopene isolation, characterization, and the evaluation of its antioxidant and antimicrobial properties, and developing a lycopene emulgel with significant photoprotection were the objectives. Lycopene was purified and identified through TLC, FTIR, and UHPLC-ESI–MS as polyene carotenoids. Purified lycopene was characterized by its high antioxidant capacity, which included high DPPH IC₅₀ value (3.2&#xa0;µg/mL) with a better reducing power than reference compounds along with protecting property in the β-carotene/linoleic acid system Moreover, lycopene showed significant antimicrobial activity against skin pathogens such as <i>Staphylococcus aureus</i>, <i>MRSA</i>, <i>Micrococcus luteus</i>, <i>Candida albicans</i> and several Gram negative bacteria responsible for infections. F1 formulation containing 0.01&#xa0;g lycopene was found to be physically stable and had appropriate pH and viscosity, homogenous consistency and maximum <i>in vitro</i> SPF value (38.8), comparable to commercial SPF 50 + sunscreens. Consequently, lycopene can be a promising natural antioxidant, antimicrobial, and photoprotective compound and its use in an emulgel for sunscreen purposes is recommended for further research and applications.</p> Graphic Abstract <p></p>

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Antioxidant, antimicrobial and photoprotective activities of a lycopene-based emulgel from Solanum lycopersicum

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Sarah Boukhalkhal,
  • Fatiha Elhouiti,
  • Anfal Zegrir,
  • Boubakeur Saidat,
  • Diana C. G. A. Pinto,
  • Artur M. S. Silva,
  • Mónica S. G. A. Válega,
  • Bouthaina Ihsan Dakmoussi,
  • Youssra Derreche,
  • Mohamed Yousfi

摘要

In this work, lycopene isolation, characterization, and the evaluation of its antioxidant and antimicrobial properties, and developing a lycopene emulgel with significant photoprotection were the objectives. Lycopene was purified and identified through TLC, FTIR, and UHPLC-ESI–MS as polyene carotenoids. Purified lycopene was characterized by its high antioxidant capacity, which included high DPPH IC₅₀ value (3.2 µg/mL) with a better reducing power than reference compounds along with protecting property in the β-carotene/linoleic acid system Moreover, lycopene showed significant antimicrobial activity against skin pathogens such as Staphylococcus aureus, MRSA, Micrococcus luteus, Candida albicans and several Gram negative bacteria responsible for infections. F1 formulation containing 0.01 g lycopene was found to be physically stable and had appropriate pH and viscosity, homogenous consistency and maximum in vitro SPF value (38.8), comparable to commercial SPF 50 + sunscreens. Consequently, lycopene can be a promising natural antioxidant, antimicrobial, and photoprotective compound and its use in an emulgel for sunscreen purposes is recommended for further research and applications.

Graphic Abstract