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<p>Sea buckthorn (<i>Hippophae rhamnoides</i>) is a deciduous woody plant of the Elaeagnaceae family. Its varied biological activities and complex chemical composition have recently attracted substantial academic attention. The objective of this review is to critically evaluate recent evidence (2021–2026) regarding the phytochemical composition, extraction technologies, pharmacological activities, clinical applications, safety profile, and future therapeutic potential of <i>Hippophae rhamnoides</i>. Flavonoids, phenolic compounds, vitamins, phytosterols, polysaccharides, essential fatty acids, and more than 190 physiologically active chemicals are known to be present in the plant. Some of its most important biological functions include cardioprotective, hepatoprotective, and neuroprotective effects, as well as reducing inflammation and the risk of cancer. New evidence from clinical trials has found that seabuckthorn may be helpful in metabolic syndrome, gastrointestinal issues, and non-alcoholic fatty liver disease (NAFLD). Furthermore, at the suggested therapeutic dosages, sea buckthorn has not been associated with any major side effects, demonstrating a solid safety margin. Ultimately, this analysis emphasizes the significance of sea buckthorn as a promising natural resource for the advancement of therapeutics and functional food uses.</p>

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Therapeutic potential and pharmacological properties of sea buckthorn (Hippophae rhamnoides) in modern healthcare

  • 期刊论文

  • 发表日期：

    2026年7月4日

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  • Bhaskar Jyoti Sharma,
  • Sunirmal Bhattacharjee,
  • Atowar Rahman

摘要

Sea buckthorn (Hippophae rhamnoides) is a deciduous woody plant of the Elaeagnaceae family. Its varied biological activities and complex chemical composition have recently attracted substantial academic attention. The objective of this review is to critically evaluate recent evidence (2021–2026) regarding the phytochemical composition, extraction technologies, pharmacological activities, clinical applications, safety profile, and future therapeutic potential of Hippophae rhamnoides. Flavonoids, phenolic compounds, vitamins, phytosterols, polysaccharides, essential fatty acids, and more than 190 physiologically active chemicals are known to be present in the plant. Some of its most important biological functions include cardioprotective, hepatoprotective, and neuroprotective effects, as well as reducing inflammation and the risk of cancer. New evidence from clinical trials has found that seabuckthorn may be helpful in metabolic syndrome, gastrointestinal issues, and non-alcoholic fatty liver disease (NAFLD). Furthermore, at the suggested therapeutic dosages, sea buckthorn has not been associated with any major side effects, demonstrating a solid safety margin. Ultimately, this analysis emphasizes the significance of sea buckthorn as a promising natural resource for the advancement of therapeutics and functional food uses.