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<p><i>Parthenium hysterophorus</i> is a weed and flowering plant belonging to the Asteraceae family. This study investigated the <i>in vitro</i> activity of <i>P. hysterophorus’s</i> aerial part. The α-amylase and α-glucosidase assays were performed to assess the anti-diabetic activity of the methanolic extract of the plant’s aerial part. In addition, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity assays were conducted to evaluate the anti-cholinesterase activity. Moreover, cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) activity assays were performed to explore the potential of <i>P. hysterophorus</i> in managing inflammation. The <i>P. hysterophorus</i> methanolic extract demonstrated α-amylase and α-glucosidase inhibition (IC<sub>50</sub> 36.46 and 123.88&#xa0;µg/mL, respectively) comparable to that of acarbose (26.58 and 21.30&#xa0;µg/mL, respectively). The methanolic extract of <i>P. hysterophorus</i> was a moderate inhibitor of AChE (61.44%) and BChE (64.98%) at a concentration of 1000&#xa0;μg/mL. In comparison to standard drugs, i.e., celecoxib (IC<sub>50</sub> 3.22&#xa0;μg/mL) and montelukast (IC<sub>50</sub> 4.50&#xa0;μg/mL), the methanolic extract of <i>P. hysterophorus</i> also exhibited significant inhibition against COX-2 and 5-LOX showing IC<sub>50</sub> values of 13.52 and 11.53&#xa0;μg/mL, respectively. Therefore, <i>P. hysterophorus</i> possessed effective anti-inflammatory, anti-diabetic, and anti-cholinesterase activities. Further in vivo and clinical studies should be conducted on specific bioactive components present in this plant to validate these therapeutic properties.</p>

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Comprehensive in-vitro study of anticholinesterase, anti-inflammatory, and antidiabetic properties of congress grass (Parthenium hysterophorus) methanolic extract

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Abdur Rauf,
  • Muhammad Ibrahim,
  • Yahya S. Al-Awthan,
  • Omar S. Bahattab,
  • Hassan A. Hemeg,
  • Anees Ahmed Khalil,
  • Ahood Khalid,
  • Samiah Shahid,
  • Hina Gull,
  • Muhammad Saeed Jan,
  • Dorota Formanowicz,
  • Marcello Iriti

摘要

Parthenium hysterophorus is a weed and flowering plant belonging to the Asteraceae family. This study investigated the in vitro activity of P. hysterophorus’s aerial part. The α-amylase and α-glucosidase assays were performed to assess the anti-diabetic activity of the methanolic extract of the plant’s aerial part. In addition, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity assays were conducted to evaluate the anti-cholinesterase activity. Moreover, cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) activity assays were performed to explore the potential of P. hysterophorus in managing inflammation. The P. hysterophorus methanolic extract demonstrated α-amylase and α-glucosidase inhibition (IC50 36.46 and 123.88 µg/mL, respectively) comparable to that of acarbose (26.58 and 21.30 µg/mL, respectively). The methanolic extract of P. hysterophorus was a moderate inhibitor of AChE (61.44%) and BChE (64.98%) at a concentration of 1000 μg/mL. In comparison to standard drugs, i.e., celecoxib (IC50 3.22 μg/mL) and montelukast (IC50 4.50 μg/mL), the methanolic extract of P. hysterophorus also exhibited significant inhibition against COX-2 and 5-LOX showing IC50 values of 13.52 and 11.53 μg/mL, respectively. Therefore, P. hysterophorus possessed effective anti-inflammatory, anti-diabetic, and anti-cholinesterase activities. Further in vivo and clinical studies should be conducted on specific bioactive components present in this plant to validate these therapeutic properties.