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<p>Diabetes causes complications from oxidative stress due to excess free radicals. Antioxidants can help manage this damage. <i>Mentha pulegium</i>, a member of the Lamiaceae family, is widely used in herbal teas and spice blends. This study investigates the chemical composition, antioxidant, and antidiabetic properties of essential oils from M. pulegium collected from three localities (S1, S2, S3) in different climatic regions. The oils were characterized using GC–MS, and their antioxidant activities were evaluated via DPPH, FRAP, and ABTS assays. Sample S1 (S1) exhibited the highest antioxidant activity in DPPH (IC<sub>50</sub> = 8700.07&#xa0;µg/mL) and FRAP (IC<sub>50</sub> = 3406.01&#xa0;µg/mL), while Sample 2 (S2) showed the strongest activity in the ABTS test (IC<sub>50</sub> = 4291.73&#xa0;µg/mL), likely due to elevated phenolic acid content and other bioactive compounds. Both S1 and S2 demonstrated moderate inhibition of α-amylase and α-glucosidase, comparable to the standard drug Acarbose. Molecular docking suggests that these essential oil components may offer insights into diabetes management and protection against oxidative stress, highlighting their potential therapeutic applications. These findings suggest that <i>M. pulegium</i> essential oils could be valuable in developing natural remedies for diabetes and oxidative stress.</p>

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Antioxidant activity, α-amylase and α-glucosidase antidiabetic potential of essential oil extracted from Mentha pulegium growing under various climate conditions: in vitro and in silico investigations

  • 期刊论文

  • 发表日期：

    2026年2月23日

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  • Abdelouahid Laftouhi,
  • Amal Elrherabi,
  • Noureddine Eloutassi,
  • Farhan Siddique,
  • Sumaira Nadeem,
  • Zakia Rais,
  • Abdeslam Taleb,
  • Yousef A. Bin Jardan,
  • Mohammed Bourhia,
  • Mustapha Taleb

摘要

Diabetes causes complications from oxidative stress due to excess free radicals. Antioxidants can help manage this damage. Mentha pulegium, a member of the Lamiaceae family, is widely used in herbal teas and spice blends. This study investigates the chemical composition, antioxidant, and antidiabetic properties of essential oils from M. pulegium collected from three localities (S1, S2, S3) in different climatic regions. The oils were characterized using GC–MS, and their antioxidant activities were evaluated via DPPH, FRAP, and ABTS assays. Sample S1 (S1) exhibited the highest antioxidant activity in DPPH (IC50 = 8700.07 µg/mL) and FRAP (IC50 = 3406.01 µg/mL), while Sample 2 (S2) showed the strongest activity in the ABTS test (IC50 = 4291.73 µg/mL), likely due to elevated phenolic acid content and other bioactive compounds. Both S1 and S2 demonstrated moderate inhibition of α-amylase and α-glucosidase, comparable to the standard drug Acarbose. Molecular docking suggests that these essential oil components may offer insights into diabetes management and protection against oxidative stress, highlighting their potential therapeutic applications. These findings suggest that M. pulegium essential oils could be valuable in developing natural remedies for diabetes and oxidative stress.