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<p>The skin is a highly organized immune organ in which resident non-immune cells cooperate with immune cells to maintain host defense and shape systemic adaptive immunity. A recent study revealed that a keratinocyte-intrinsic farnesyl pyrophosphate-transient receptor potential vanilloid 3 pathway transforms epidermal stress into interleukin-6- and chemokine-dependent signals that promote dendritic cell migration, T follicular helper-cell expansion and germinal center activity, thereby amplifying humoral immunity and autoimmunity.</p>

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Beyond barrier function: keratinocytes as orchestrators of humoral immunity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月16日

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  • Chaohuan Guo,
  • George C. Tsokos

摘要

The skin is a highly organized immune organ in which resident non-immune cells cooperate with immune cells to maintain host defense and shape systemic adaptive immunity. A recent study revealed that a keratinocyte-intrinsic farnesyl pyrophosphate-transient receptor potential vanilloid 3 pathway transforms epidermal stress into interleukin-6- and chemokine-dependent signals that promote dendritic cell migration, T follicular helper-cell expansion and germinal center activity, thereby amplifying humoral immunity and autoimmunity.