Scholarlink

<p>In the present work, an ultrasound-assisted one-pot biogenic synthesis of extract coated-maghemite iron oxide nanoparticles (γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs) in an alkaline solution mediated by <i>Mentha pulegium</i> extract was described. The biosynthesized maghemite γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs were characterized through SEM, TEM, FT-IR, EDX, VSM and XRD. The produced γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs shown remarkable catalytic efficiency in the production of pyrano[2,3-d]pyrimidines via a three-component condensation that included barbituric acid, aryl aldehydes, and malononitrile. Furthermore, the γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs displayed good recyclability for 7 times without notable lose in activity. The fatal dosage of <i>P. aeruginosa</i> is assessed in Swiss albino mice as part of an in vivo investigation, and the clinical manifestations—such as bacteremia, hypothermia, and weight loss—are analyzed 48&#xa0;h after infection. Infected mice's physical manifestations revealed a 20% weight loss after the trial and a considerable drop in body temperature, from 38.7 to 34.6 C. Furthermore, using bacteremia, histology, and radiological examination, the effectiveness of γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs against lung infection caused by the projected fatal dose was assessed. On day 7, the bacterial burden was 0.2 Log10CFU/mL in the γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs group, which was much lower than the bacterial burden on day 1, which was 1.8 Log10CFU/mL. According to the study, 100&#xa0;µg/kg of the γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs extract is effective against <i>P. aeruginosa</i>-induced lung infections. The goal of recent work was to build a powerful regimen against this dangerous infection by further using the biological features of γ-Fe<sub>2</sub>O<sub>3</sub>@<i>M. pulegium</i> NPs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Green synthesis of maghemite iron oxide nanoparticles mediated by Mentha pulegium extract: Its application for one-pot preparation of pyrano[2,3-d]pyrimidines and its treatment for Pseudomonas aeruginosa-induced lung infection

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月22日

查看全文
  • Jingyao Zhang,
  • Attalla F. El-kott,
  • Sally Negm,
  • Mohammed A. AlShehri,
  • Salama A. Salama,
  • Abdullah Ali Alamri,
  • Samiah A. Alhabardi,
  • Bikash Karmakar

摘要

In the present work, an ultrasound-assisted one-pot biogenic synthesis of extract coated-maghemite iron oxide nanoparticles (γ-Fe2O3@M. pulegium NPs) in an alkaline solution mediated by Mentha pulegium extract was described. The biosynthesized maghemite γ-Fe2O3@M. pulegium NPs were characterized through SEM, TEM, FT-IR, EDX, VSM and XRD. The produced γ-Fe2O3@M. pulegium NPs shown remarkable catalytic efficiency in the production of pyrano[2,3-d]pyrimidines via a three-component condensation that included barbituric acid, aryl aldehydes, and malononitrile. Furthermore, the γ-Fe2O3@M. pulegium NPs displayed good recyclability for 7 times without notable lose in activity. The fatal dosage of P. aeruginosa is assessed in Swiss albino mice as part of an in vivo investigation, and the clinical manifestations—such as bacteremia, hypothermia, and weight loss—are analyzed 48 h after infection. Infected mice's physical manifestations revealed a 20% weight loss after the trial and a considerable drop in body temperature, from 38.7 to 34.6 C. Furthermore, using bacteremia, histology, and radiological examination, the effectiveness of γ-Fe2O3@M. pulegium NPs against lung infection caused by the projected fatal dose was assessed. On day 7, the bacterial burden was 0.2 Log10CFU/mL in the γ-Fe2O3@M. pulegium NPs group, which was much lower than the bacterial burden on day 1, which was 1.8 Log10CFU/mL. According to the study, 100 µg/kg of the γ-Fe2O3@M. pulegium NPs extract is effective against P. aeruginosa-induced lung infections. The goal of recent work was to build a powerful regimen against this dangerous infection by further using the biological features of γ-Fe2O3@M. pulegium NPs.