<p>We develop and analyse a Caputo fractional-order SEIVR epidemic model for COVID-19 incorporating detected and undetected infectious compartments, saturated treatment reflecting healthcare-capacity constraints, waning vaccine immunity, and memory effects governed by fractional order <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\alpha \in (0,1]\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>α</mi> <mo>∈</mo> <mo stretchy="false">(</mo> <mn>0</mn> <mo>,</mo> <mn>1</mn> <mo stretchy="false">]</mo> </mrow> </math></EquationSource> </InlineEquation>. Positivity and uniform boundedness of all solutions are established, and the unique positively invariant region&#xa0;<InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(\Omega \)</EquationSource> <EquationSource Format="MATHML"><math> <mi mathvariant="normal">Ω</mi> </math></EquationSource> </InlineEquation> is identified. The basic reproduction number <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(\mathcal {R}_0 = \mathcal {R}_d + \mathcal {R}_u\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi mathvariant="script">R</mi> <mn>0</mn> </msub> <mo>=</mo> <msub> <mi mathvariant="script">R</mi> <mi>d</mi> </msub> <mo>+</mo> <msub> <mi mathvariant="script">R</mi> <mi>u</mi> </msub> </mrow> </math></EquationSource> </InlineEquation> is derived via the next-generation matrix method. Local asymptotic stability of the disease-free equilibrium&#xa0;(DFE) is proved using the Matignon criterion when <InlineEquation ID="IEq4"> <EquationSource Format="TEX">\(\mathcal {R}_0&lt;1\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi mathvariant="script">R</mi> <mn>0</mn> </msub> <mo>&lt;</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation>, with instability when <InlineEquation ID="IEq5"> <EquationSource Format="TEX">\(\mathcal {R}_0&gt;1\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi mathvariant="script">R</mi> <mn>0</mn> </msub> <mo>&gt;</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation>. Global asymptotic stability of both the DFE and the unique endemic equilibrium is established via Volterra-type Lyapunov functions adapted to Caputo systems. A centre-manifold backward bifurcation analysis reveals that a stable endemic equilibrium can coexist with the stable DFE, requiring the vaccination rate to exceed a critical threshold <InlineEquation ID="IEq6"> <EquationSource Format="TEX">\(\phi _c\approx 0.0043\,\text {day}^{-1}\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi>ϕ</mi> <mi>c</mi> </msub> <mo>≈</mo> <mn>0.0043</mn> <mspace width="0.166667em" /> <msup> <mtext>day</mtext> <mrow> <mo>-</mo> <mn>1</mn> </mrow> </msup> </mrow> </math></EquationSource> </InlineEquation> for disease elimination. Three additional contributions are made: (i)&#xa0;a closed-form vaccination reproduction number <InlineEquation ID="IEq7"> <EquationSource Format="TEX">\(\mathcal {R}_v(\phi )\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi mathvariant="script">R</mi> <mi>v</mi> </msub> <mrow> <mo stretchy="false">(</mo> <mi>ϕ</mi> <mo stretchy="false">)</mo> </mrow> </mrow> </math></EquationSource> </InlineEquation> with a herd-immunity threshold of <InlineEquation ID="IEq8"> <EquationSource Format="TEX">\(45.9\,\%\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>45.9</mn> <mspace width="0.166667em" /> <mo>%</mo> </mrow> </math></EquationSource> </InlineEquation> at baseline <InlineEquation ID="IEq9"> <EquationSource Format="TEX">\(\mathcal {R}_0=1.85\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi mathvariant="script">R</mi> <mn>0</mn> </msub> <mo>=</mo> <mn>1.85</mn> </mrow> </math></EquationSource> </InlineEquation>; (ii)&#xa0;a quantitative comparison of fractional versus integer-order stability regions, showing the Matignon angle threshold expands the stable manifold by up to <InlineEquation ID="IEq10"> <EquationSource Format="TEX">\(30\,\%\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>30</mn> <mspace width="0.166667em" /> <mo>%</mo> </mrow> </math></EquationSource> </InlineEquation> at <InlineEquation ID="IEq11"> <EquationSource Format="TEX">\(\alpha =0.7\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>α</mi> <mo>=</mo> <mn>0.7</mn> </mrow> </math></EquationSource> </InlineEquation>; and (iii)&#xa0;a monotone sensitivity analysis confirming that <InlineEquation ID="IEq12"> <EquationSource Format="TEX">\(\phi _c\)</EquationSource> <EquationSource Format="MATHML"><math> <msub> <mi>ϕ</mi> <mi>c</mi> </msub> </math></EquationSource> </InlineEquation> strictly increases with&#xa0;<InlineEquation ID="IEq13"> <EquationSource Format="TEX">\(\kappa \)</EquationSource> <EquationSource Format="MATHML"><math> <mi>κ</mi> </math></EquationSource> </InlineEquation>, formalising treatment saturation as the key driver of bifurcation severity.</p>

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Stability and bifurcation dynamics of a fractional-order two-strain COVID-19 model

  • P. Thakur,
  • K. Srivastava,
  • V. Singh,
  • S. K. Srivastava

摘要

We develop and analyse a Caputo fractional-order SEIVR epidemic model for COVID-19 incorporating detected and undetected infectious compartments, saturated treatment reflecting healthcare-capacity constraints, waning vaccine immunity, and memory effects governed by fractional order \(\alpha \in (0,1]\) α ( 0 , 1 ] . Positivity and uniform boundedness of all solutions are established, and the unique positively invariant region  \(\Omega \) Ω is identified. The basic reproduction number \(\mathcal {R}_0 = \mathcal {R}_d + \mathcal {R}_u\) R 0 = R d + R u is derived via the next-generation matrix method. Local asymptotic stability of the disease-free equilibrium (DFE) is proved using the Matignon criterion when \(\mathcal {R}_0<1\) R 0 < 1 , with instability when \(\mathcal {R}_0>1\) R 0 > 1 . Global asymptotic stability of both the DFE and the unique endemic equilibrium is established via Volterra-type Lyapunov functions adapted to Caputo systems. A centre-manifold backward bifurcation analysis reveals that a stable endemic equilibrium can coexist with the stable DFE, requiring the vaccination rate to exceed a critical threshold \(\phi _c\approx 0.0043\,\text {day}^{-1}\) ϕ c 0.0043 day - 1 for disease elimination. Three additional contributions are made: (i) a closed-form vaccination reproduction number \(\mathcal {R}_v(\phi )\) R v ( ϕ ) with a herd-immunity threshold of \(45.9\,\%\) 45.9 % at baseline \(\mathcal {R}_0=1.85\) R 0 = 1.85 ; (ii) a quantitative comparison of fractional versus integer-order stability regions, showing the Matignon angle threshold expands the stable manifold by up to \(30\,\%\) 30 % at \(\alpha =0.7\) α = 0.7 ; and (iii) a monotone sensitivity analysis confirming that \(\phi _c\) ϕ c strictly increases with  \(\kappa \) κ , formalising treatment saturation as the key driver of bifurcation severity.