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<p>Mad honey has been traditionally used in the Black Sea region of Türkiye in relation to male sexual function, yet its underlying physiological mechanisms remain unclear. In this study, we explored how acute and chronic mad honey exposure affects sexual behavior and androgen-related endocrine parameters in adult male rats. Thirty-six sexually experienced rats were assigned to acute (single-dose) or chronic (30-day) treatment protocols and received saline, pine honey, or mad honey. Serum and testicular levels of testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and 5-alpha-reductase (5αR) were measured, and sexual behavior was assessed using established experimental paradigms. While testicular hormone levels remained unchanged, mad honey administration led to significant increases in serum T and 5αR without altering FSH or LH. Behaviorally, acute mad honey exposure prolonged ejaculation latency, whereas chronic treatment shortened the post-ejaculatory interval. These findings suggest that mad honey modulates circulating androgen-related parameters and sexual behavior through time-dependent mechanisms, although the functional significance of the total testosterone increase requires further investigation.</p> Graphical abstract <p></p>

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Mad Honey Modulates Reproductive Hormones and Sexual Behavior in Male Rats

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月3日

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  • Kutluhan Furkan Gül,
  • Tuba Gül,
  • Nazife Ülker Ertuğrul,
  • Zafer Şahin,
  • Özgür Bulmuş,
  • Sinan Paslı,
  • Selim Demir,
  • Özgür Tatlı,
  • Arif Kamil Salihoğlu,
  • Abdülkadir Gündüz

摘要

Mad honey has been traditionally used in the Black Sea region of Türkiye in relation to male sexual function, yet its underlying physiological mechanisms remain unclear. In this study, we explored how acute and chronic mad honey exposure affects sexual behavior and androgen-related endocrine parameters in adult male rats. Thirty-six sexually experienced rats were assigned to acute (single-dose) or chronic (30-day) treatment protocols and received saline, pine honey, or mad honey. Serum and testicular levels of testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and 5-alpha-reductase (5αR) were measured, and sexual behavior was assessed using established experimental paradigms. While testicular hormone levels remained unchanged, mad honey administration led to significant increases in serum T and 5αR without altering FSH or LH. Behaviorally, acute mad honey exposure prolonged ejaculation latency, whereas chronic treatment shortened the post-ejaculatory interval. These findings suggest that mad honey modulates circulating androgen-related parameters and sexual behavior through time-dependent mechanisms, although the functional significance of the total testosterone increase requires further investigation.

Graphical abstract