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Background <p>Cyclophosphamide (CYC) is one of the most commonly used chemotherapy drugs, but it carries a high risk of damage to the ovaries. The current study aims to investigate the potential therapeutic effects of Cordycepin on cyclophosphamide (CYC)-induced ovarian damage by evaluating histological and biochemical parameters.</p> Methods <p>Forty female Wistar albino rats were randomly divided into four groups: Group 1 (Sham), Group 2 (CYC), Group 3 (CYC + 3&#xa0;mg/kg cordycepin), and Group 4 (CYC + 10&#xa0;mg/kg cordycepin). Cordycepin was administered orally by gavage for 10 consecutive days. On day 5, a single intraperitoneal dose of 150&#xa0;mg/kg CYC was administered to groups 2,3 and 4. Ovarian damage and reserve were assessed using histological evaluation and serum/tissue biochemical markers.</p> Results <p>Cordycepin treatment significantly increased serum anti-Müllerian hormone and inhibin B levels while reducing ovarian histopathological damage scores (<i>p</i> &lt; 0.05). It also decreased malondialdehyde (MDA) levels and enhanced superoxide dismutase (SOD) activity and glutathione (GSH) levels (<i>p</i> &lt; 0.05). Elevated levels of phosphorylated nuclear factor-κB (phospho-NF-κB p65), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), γH2AX immunoreactivity, and TUNEL assay positivity observed in the CYC group were significantly reduced by cordycepin treatment (<i>p</i> &lt; 0.05).</p> Conclusion <p>Cordycepin exerts protective effects against CYC-induced ovarian toxicity through its antioxidant, anti-inflammatory, and antiapoptotic properties, improving both ovarian structure and function.</p>

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Protective Effect of Cordycepin Against Cyclophosphamide-Induced Ovarian Damage in Rats via Antioxidant, Anti-Inflammatory and Antiapoptotic Mechanisms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月14日

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  • Melike Demir Çaltekin,
  • Emin Kaymak,
  • Taylan Onat,
  • Yakup Yalçın,
  • Adem Tokpınar,
  • Mahmud Mustafa Ozkut

摘要

Background

Cyclophosphamide (CYC) is one of the most commonly used chemotherapy drugs, but it carries a high risk of damage to the ovaries. The current study aims to investigate the potential therapeutic effects of Cordycepin on cyclophosphamide (CYC)-induced ovarian damage by evaluating histological and biochemical parameters.

Methods

Forty female Wistar albino rats were randomly divided into four groups: Group 1 (Sham), Group 2 (CYC), Group 3 (CYC + 3 mg/kg cordycepin), and Group 4 (CYC + 10 mg/kg cordycepin). Cordycepin was administered orally by gavage for 10 consecutive days. On day 5, a single intraperitoneal dose of 150 mg/kg CYC was administered to groups 2,3 and 4. Ovarian damage and reserve were assessed using histological evaluation and serum/tissue biochemical markers.

Results

Cordycepin treatment significantly increased serum anti-Müllerian hormone and inhibin B levels while reducing ovarian histopathological damage scores (p < 0.05). It also decreased malondialdehyde (MDA) levels and enhanced superoxide dismutase (SOD) activity and glutathione (GSH) levels (p < 0.05). Elevated levels of phosphorylated nuclear factor-κB (phospho-NF-κB p65), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), γH2AX immunoreactivity, and TUNEL assay positivity observed in the CYC group were significantly reduced by cordycepin treatment (p < 0.05).

Conclusion

Cordycepin exerts protective effects against CYC-induced ovarian toxicity through its antioxidant, anti-inflammatory, and antiapoptotic properties, improving both ovarian structure and function.