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<p>Circadian rhythms (CR) are endogenous, self-sustained oscillations generated by the molecular circadian clock, which synchronizes internal physiological processes with the external 24-h light–dark cycle. The circadian clock plays an important role in regulating nearly all physiological functions, and disruptions in this biological clock may have serious effects on the human health. CR disruption is a prevalent problem in modern society. Lifestyle, genetics, the rotation of the Earth, and seasonal conditions can all influence circadian rhythm. Therefore, the circadian system controls the internal processes of the body and regulates how it responds to environmental factors. Dysregulation of the circadian clock also known as chronodisruption, has been linked to a number of non-communicable diseases, including cancer, metabolic disease, bone and muscle disease, autoimmune disease, sleep disorders, and cardiovascular disease. Regarding this, various therapies have been found to resolve circadian disruption, including chronobiotics and light therapy. This review paper elucidates the amalgamation among circadian rhythm and non-communicable diseases in addition to certain clock-based treatment strategies that could be useful in clinical implications. Future advancements in these interventions may help in the development of effective chronotherapy approaches, which might improve the clinical outcomes.</p>

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Unraveling the Tapestry of Health: The Intricate Dance of Circadian Rhythms and Human Diseases

  • 期刊论文

  • 发表日期：

    2026年1月14日

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  • Sidrah Parvez,
  • Andrej Dzupina,
  • Ghizal Fatima,
  • Najah Hadi,
  • Jan Fedacko,
  • Aminat Magomedova,
  • Ammar Mehdi Raza,
  • Nasser Ghaly Yousif,
  • Hekmat B. Alhmadi

摘要

Circadian rhythms (CR) are endogenous, self-sustained oscillations generated by the molecular circadian clock, which synchronizes internal physiological processes with the external 24-h light–dark cycle. The circadian clock plays an important role in regulating nearly all physiological functions, and disruptions in this biological clock may have serious effects on the human health. CR disruption is a prevalent problem in modern society. Lifestyle, genetics, the rotation of the Earth, and seasonal conditions can all influence circadian rhythm. Therefore, the circadian system controls the internal processes of the body and regulates how it responds to environmental factors. Dysregulation of the circadian clock also known as chronodisruption, has been linked to a number of non-communicable diseases, including cancer, metabolic disease, bone and muscle disease, autoimmune disease, sleep disorders, and cardiovascular disease. Regarding this, various therapies have been found to resolve circadian disruption, including chronobiotics and light therapy. This review paper elucidates the amalgamation among circadian rhythm and non-communicable diseases in addition to certain clock-based treatment strategies that could be useful in clinical implications. Future advancements in these interventions may help in the development of effective chronotherapy approaches, which might improve the clinical outcomes.