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<p>Tendon injuries constitute a major source of musculoskeletal disability, often resulting in chronic dysfunction and substantial socioeconomic burden. Their multifactorial etiology involves both intrinsic factors, such as aging and metabolic imbalance, and extrinsic mechanical stressors. Oxidative stress has emerged as a key contributor to tendon degeneration, compromising extracellular matrix integrity and cellular function. Tendon healing is a dynamic process integrating inflammation, cellular proliferation, and remodeling. Recent evidence highlights the therapeutic potential of antioxidants in modulating redox balance and enhancing regenerative outcomes. Overall, this review underscores the interplay between oxidative stress and tendon repair, emphasizing the potential of antioxidant-based interventions to improve functional recovery and clinical prognosis.</p>

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The Interplay Between Redox Imbalance, Inflammatory Signaling and Mechanical Factors in Tendon Recovery

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Seher Yilmaz,
  • Şükrü Ateş,
  • Sümeyye Uçar,
  • Figen Yılmaz

摘要

Tendon injuries constitute a major source of musculoskeletal disability, often resulting in chronic dysfunction and substantial socioeconomic burden. Their multifactorial etiology involves both intrinsic factors, such as aging and metabolic imbalance, and extrinsic mechanical stressors. Oxidative stress has emerged as a key contributor to tendon degeneration, compromising extracellular matrix integrity and cellular function. Tendon healing is a dynamic process integrating inflammation, cellular proliferation, and remodeling. Recent evidence highlights the therapeutic potential of antioxidants in modulating redox balance and enhancing regenerative outcomes. Overall, this review underscores the interplay between oxidative stress and tendon repair, emphasizing the potential of antioxidant-based interventions to improve functional recovery and clinical prognosis.