Scholarlink

Purpose <p>Lichen planus (LP) is a chronic inflammatory disease affecting squamous epithelia, potentially impacting various epithelian surfaces, particularly the skin, oral mucosa, and nails. Mucosal involvement is clinically significant due to its influence on disease course and complications. Mucociliary activity plays a critical role in the defense mechanisms of the respiratory tract, and the potential impact of LP on this activity remains unknown. This study aims to investigate changes in nasal mucociliary activity (NMCT) in patients with LP and to examine the effects of any changes on respiratory health.</p> Patients and methods <p>The study included 30 patients with LP and 31 healthy controls. NMCT was measured using the saccharin transit time test. A 1 mm3 saccharin tablet was placed approximately 1&#xa0;cm posterior to the anterior edge of the inferior turbinate in the left nasal cavity of each participant. NMCT was measured with a chronometer.</p> Results <p>NMCT in LP patients was 9.890 ± 1.800&#xa0;min, while in the control group, it was 7.835 ± 1.530&#xa0;min (p &lt; 0.001). NMCT was significantly longer in LP patients with oral mucosal involvement compared to those without mucosal involvement (p = 0.044). NMCT tended to be longer in patients with nail involvement, but this difference was not statistically significant (p = 0.096).</p> Conclusion <p>Prolonged mucociliary clearance in patients with LP (especially those with mucosal involvement) may increase the risk of respiratory tract infections and negatively impact patients’ quality of life. This finding highlights the importance of evaluating NMCT in LP patients and investigating potential therapeutic interventions to improve it.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impaired Nasal Mucociliary Clearance in Patients with Lichen Planus: Association with Mucosal Involvement

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月27日

查看全文
  • Elif Emre,
  • Selami Aykut Temiz,
  • Sadettin Emre,
  • Mehmet Akif Dündar,
  • Munise Daye

摘要

Purpose

Lichen planus (LP) is a chronic inflammatory disease affecting squamous epithelia, potentially impacting various epithelian surfaces, particularly the skin, oral mucosa, and nails. Mucosal involvement is clinically significant due to its influence on disease course and complications. Mucociliary activity plays a critical role in the defense mechanisms of the respiratory tract, and the potential impact of LP on this activity remains unknown. This study aims to investigate changes in nasal mucociliary activity (NMCT) in patients with LP and to examine the effects of any changes on respiratory health.

Patients and methods

The study included 30 patients with LP and 31 healthy controls. NMCT was measured using the saccharin transit time test. A 1 mm3 saccharin tablet was placed approximately 1 cm posterior to the anterior edge of the inferior turbinate in the left nasal cavity of each participant. NMCT was measured with a chronometer.

Results

NMCT in LP patients was 9.890 ± 1.800 min, while in the control group, it was 7.835 ± 1.530 min (p < 0.001). NMCT was significantly longer in LP patients with oral mucosal involvement compared to those without mucosal involvement (p = 0.044). NMCT tended to be longer in patients with nail involvement, but this difference was not statistically significant (p = 0.096).

Conclusion

Prolonged mucociliary clearance in patients with LP (especially those with mucosal involvement) may increase the risk of respiratory tract infections and negatively impact patients’ quality of life. This finding highlights the importance of evaluating NMCT in LP patients and investigating potential therapeutic interventions to improve it.