Scholarlink

Introduction <p>Interest in low-fresh-gas flow anaesthesia methods has recently increased. Low-flow anaesthesia protocols expect low inspired oxygen because of the limited gas supply to the rebreathing circuit. Our hypothesis was that different fresh gas flow rates could result in different oxidative stress responses while maintaining the same oxygen concentration (FiO<sub>2</sub> 0.50).</p> Methods <p>Seventy-six patients undergoing general anaesthesia were randomised into low-flow (1 L/min) and high-flow (4 L/min) anaesthesia groups. The FiO<sub>2</sub> was standardised at 0.50 for all patients. Total oxidant status, total antioxidant status, and oxidative stress index were measured preoperatively, at the 30th minute intraoperatively, and at the 6th hour postoperatively. Total oxidant status was the primary outcome. Secondary outcomes included total antioxidant status, oxidative stress index, albumin, C-reactive protein, partial arterial oxygen pressure, vitamin D, and haemodynamics. The statistical analysis included 72 participants who completed the study.</p> Results <p>For total oxidant status, total antioxidant status, and oxidative stress index, the group&#xa0;×&#xa0;time interaction was not significant (p = 0.748, p = 0.417, and p = 0.402, respectively). Total oxidant status, total antioxidant status, and oxidative stress index changed similarly over time in both groups. However, the change in total antioxidant status over time was significant (p = 0.009). This difference was observed between preoperative and intraoperative (30&#xa0;min) (p = 0.006) and preoperative and postoperative (6&#xa0;h) (p = 0.020) values, but not between intraoperative (30&#xa0;min) and postoperative (6&#xa0;h) values (p = 0.774). The group effects on total oxidant status, total antioxidant status, and oxidative stress index were insignificant (p = 0.784, p = 0.254, and p = 0.698, respectively).</p> Conclusion <p>Total antioxidant status was higher during the intraoperative and postoperative periods than preoperatively, regardless of the low-flow or high-flow anaesthesia technique. The elevation of total antioxidant status during intraoperative and postoperative periods may have helped maintain total oxidant status and reduce oxidative stress due to increased antioxidant levels.</p> Trial Registration <p>This study was retrospectively registered in the ClinicalTrials. gov database (NCT05590312; 18 October 2022).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Oxidative Stress in Low-Flow and High-Flow General Anaesthesia: A Single-Centre Prospective Randomised Trial

  • 期刊论文

  • 发表日期：

    2025年11月1日

查看全文
  • Guner Sobcali,
  • Ozlem Ersoy Karka,
  • Mehmet Ali Sungur,
  • Fatih Davran,
  • Gizem Demir Senoglu,
  • Ilknur Suidiye Yorulmaz,
  • Gulbin Sezen,
  • Yavuz Demiraran

摘要

Introduction

Interest in low-fresh-gas flow anaesthesia methods has recently increased. Low-flow anaesthesia protocols expect low inspired oxygen because of the limited gas supply to the rebreathing circuit. Our hypothesis was that different fresh gas flow rates could result in different oxidative stress responses while maintaining the same oxygen concentration (FiO2 0.50).

Methods

Seventy-six patients undergoing general anaesthesia were randomised into low-flow (1 L/min) and high-flow (4 L/min) anaesthesia groups. The FiO2 was standardised at 0.50 for all patients. Total oxidant status, total antioxidant status, and oxidative stress index were measured preoperatively, at the 30th minute intraoperatively, and at the 6th hour postoperatively. Total oxidant status was the primary outcome. Secondary outcomes included total antioxidant status, oxidative stress index, albumin, C-reactive protein, partial arterial oxygen pressure, vitamin D, and haemodynamics. The statistical analysis included 72 participants who completed the study.

Results

For total oxidant status, total antioxidant status, and oxidative stress index, the group × time interaction was not significant (p = 0.748, p = 0.417, and p = 0.402, respectively). Total oxidant status, total antioxidant status, and oxidative stress index changed similarly over time in both groups. However, the change in total antioxidant status over time was significant (p = 0.009). This difference was observed between preoperative and intraoperative (30 min) (p = 0.006) and preoperative and postoperative (6 h) (p = 0.020) values, but not between intraoperative (30 min) and postoperative (6 h) values (p = 0.774). The group effects on total oxidant status, total antioxidant status, and oxidative stress index were insignificant (p = 0.784, p = 0.254, and p = 0.698, respectively).

Conclusion

Total antioxidant status was higher during the intraoperative and postoperative periods than preoperatively, regardless of the low-flow or high-flow anaesthesia technique. The elevation of total antioxidant status during intraoperative and postoperative periods may have helped maintain total oxidant status and reduce oxidative stress due to increased antioxidant levels.

Trial Registration

This study was retrospectively registered in the ClinicalTrials. gov database (NCT05590312; 18 October 2022).