Scholarlink

<p>Prostate cancer remains the most commonly diagnosed malignancy in men worldwide, representing a major health challenge due to its heterogeneity, aggressive progression, and resistance to conventional therapies. Although improvements in diagnostic imaging, PSA screening, and targeted therapies have advanced clinical management, prostate cancer still presents substantial clinical challenges, notably progression to castration-resistant prostate cancer (CRPC) and metastatic disease. Recent research emphasizes the importance of non-coding RNAs (ncRNAs), including microRNAs, small interfering RNAs, PIWI-interacting RNAs, small nucleolar RNAs, small nuclear RNAs, transfer RNA-derived small RNAs, YRNAs, vault RNAs, circular RNAs, and long non-coding RNAs, in the regulation of gene expression, signaling pathways, tumor growth, metastasis, and therapy resistance. This review comprehensively synthesizes the current understanding of ncRNAs in prostate cancer, highlighting their diverse regulatory functions, interactions, clinical implications, and potential as biomarkers and therapeutic targets. By integrating existing knowledge and exploring novel molecular mechanisms, we aim to facilitate the way to personalized prostate cancer management, stratification of patient risk, and precision therapeutic strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of Non-Coding RNAs in Prostate Cancer: Diagnosis, Prognosis, and Therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月5日

查看全文
  • Zuzana Varchulova Novakova,
  • Lubica Milosovicova,
  • Sona Bernatova,
  • Lucia Neuschlova,
  • Stefan Harsanyi

摘要

Prostate cancer remains the most commonly diagnosed malignancy in men worldwide, representing a major health challenge due to its heterogeneity, aggressive progression, and resistance to conventional therapies. Although improvements in diagnostic imaging, PSA screening, and targeted therapies have advanced clinical management, prostate cancer still presents substantial clinical challenges, notably progression to castration-resistant prostate cancer (CRPC) and metastatic disease. Recent research emphasizes the importance of non-coding RNAs (ncRNAs), including microRNAs, small interfering RNAs, PIWI-interacting RNAs, small nucleolar RNAs, small nuclear RNAs, transfer RNA-derived small RNAs, YRNAs, vault RNAs, circular RNAs, and long non-coding RNAs, in the regulation of gene expression, signaling pathways, tumor growth, metastasis, and therapy resistance. This review comprehensively synthesizes the current understanding of ncRNAs in prostate cancer, highlighting their diverse regulatory functions, interactions, clinical implications, and potential as biomarkers and therapeutic targets. By integrating existing knowledge and exploring novel molecular mechanisms, we aim to facilitate the way to personalized prostate cancer management, stratification of patient risk, and precision therapeutic strategies.