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Aim <p>The present study aimed to examine the effect of vitamin D receptor agonist paricalcitol (PRC) on doxorubicin (DOX)-induced thyroid gland damage in rats.</p> Materials and Methods <p>Twenty-eight Wistar rats were randomly categorized into four groups: (1) control (SF; 2&#xa0;ml/kg); (2) DOX (18&#xa0;µg/kg), (3) PRC (0.5&#xa0;μg/kg) and (4) PRC (1&#xa0;μg/kg). PRC was administered three times a week for 21&#xa0;days. In PRC and 18&#xa0;µg/kg DOX groups, drugs were administered on the 19th, 20th or 21st days of the experiment. On the 22nd day, <sup>99m</sup>Tc pertechnetate uptake level and serum biochemical parameters were determined.</p> Results <p><sup>99m</sup>Tc pertechnetate uptake was lower in groups receiving DOX and/or 0.5 and 1&#xa0;μg/kg PRC than in control groups. The <sup>99m</sup>Tc pertechnetate levels in the 0.5 and 1&#xa0;μg/kg PRC groups were significantly higher than the DOX group. However, PRC pretreatments decreased <sup>99m</sup>Tc pertechnetate uptake in rat thyroid gland. Besides, DOX caused a significant increase in blood TSH levels and decreases in T3 and T4 levels compared to the control groups. Administration of PRC decreased TSH level and increased T3 and T4 levels compared to DOX group.</p> Conclusion <p>PRC administration protects thyroid gland against DOX-induced toxicity.</p>

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Protective Effect of Paricalcitol on Doxorubicin-Induced Thyroid Dysfunction in Rats

  • 期刊论文

  • 发表日期：

    2025年3月24日

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  • Reyhan Köroglu,
  • Hatice Aygun

摘要

Aim

The present study aimed to examine the effect of vitamin D receptor agonist paricalcitol (PRC) on doxorubicin (DOX)-induced thyroid gland damage in rats.

Materials and Methods

Twenty-eight Wistar rats were randomly categorized into four groups: (1) control (SF; 2 ml/kg); (2) DOX (18 µg/kg), (3) PRC (0.5 μg/kg) and (4) PRC (1 μg/kg). PRC was administered three times a week for 21 days. In PRC and 18 µg/kg DOX groups, drugs were administered on the 19th, 20th or 21st days of the experiment. On the 22nd day, 99mTc pertechnetate uptake level and serum biochemical parameters were determined.

Results

99mTc pertechnetate uptake was lower in groups receiving DOX and/or 0.5 and 1 μg/kg PRC than in control groups. The 99mTc pertechnetate levels in the 0.5 and 1 μg/kg PRC groups were significantly higher than the DOX group. However, PRC pretreatments decreased 99mTc pertechnetate uptake in rat thyroid gland. Besides, DOX caused a significant increase in blood TSH levels and decreases in T3 and T4 levels compared to the control groups. Administration of PRC decreased TSH level and increased T3 and T4 levels compared to DOX group.

Conclusion

PRC administration protects thyroid gland against DOX-induced toxicity.