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Background <p>Intraductal papillary mucinous neoplasms (IPMN) often coexist with acute or chronic pancreatitis, which can complicate laparoscopic spleen-preserving distal pancreatectomy (LSPDP), especially with splenic vessel preservation (SVP-LSPDP). This study aims to evaluate the safety, feasibility, and long-term outcomes of SVP-LSPDP for IPMN.</p> Methods <p>A retrospective study was conducted on IPMN patients who underwent SVP-LSPDP between November 2017 and December 2022. Demographics, surgical outcomes, pathology reports, complication rates, mortality, and follow-up data (as of April 2023) were analyzed.</p> Results <p>The study included 21 patients who underwent SVP-LSPDP, with a median age of 62 (range 32–81) years. The operation time, intraoperative blood loss, and postoperative hospital stay were 185.52 ± 68.2&#xa0;min, 89 ± 88.73&#xa0;ml, and 9 (range 3–27) days, respectively. The Clavien-Dindo Grade II, Grade III, and Grade B pancreatic fistulas were 4.8%, 0, and 9.5%, respectively, with no fatal cases. The follow-up rate was 100%, with a median follow-up period of 27 (range 6–65) months. All patients survived without tumor recurrence or metastasis. Six patients developed new-onset diabetes after surgery, but exocrine pancreatic insufficiency was not observed in any patient. No patient developed splenic infarction or perigastric varices.</p> Conclusion <p>For IPMN cases in the body and tail of the pancreas, SVP-LSPDP is a safe and feasible surgical approach with good short- and long-term outcomes.</p>

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Short- and Long-Term Outcomes of Laparoscopic Spleen-Preserving Distal Pancreatectomy with Splenic Vessel Preservation for Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Single-Center Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月17日

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  • Yu Cai,
  • Pan Gao,
  • Qiangxin Chen,
  • Zixin Chen,
  • Ke Cheng,
  • He Cai,
  • Yunqiang Cai,
  • Xin Wang,
  • Zhong Wu,
  • Bing Peng

摘要

Background

Intraductal papillary mucinous neoplasms (IPMN) often coexist with acute or chronic pancreatitis, which can complicate laparoscopic spleen-preserving distal pancreatectomy (LSPDP), especially with splenic vessel preservation (SVP-LSPDP). This study aims to evaluate the safety, feasibility, and long-term outcomes of SVP-LSPDP for IPMN.

Methods

A retrospective study was conducted on IPMN patients who underwent SVP-LSPDP between November 2017 and December 2022. Demographics, surgical outcomes, pathology reports, complication rates, mortality, and follow-up data (as of April 2023) were analyzed.

Results

The study included 21 patients who underwent SVP-LSPDP, with a median age of 62 (range 32–81) years. The operation time, intraoperative blood loss, and postoperative hospital stay were 185.52 ± 68.2 min, 89 ± 88.73 ml, and 9 (range 3–27) days, respectively. The Clavien-Dindo Grade II, Grade III, and Grade B pancreatic fistulas were 4.8%, 0, and 9.5%, respectively, with no fatal cases. The follow-up rate was 100%, with a median follow-up period of 27 (range 6–65) months. All patients survived without tumor recurrence or metastasis. Six patients developed new-onset diabetes after surgery, but exocrine pancreatic insufficiency was not observed in any patient. No patient developed splenic infarction or perigastric varices.

Conclusion

For IPMN cases in the body and tail of the pancreas, SVP-LSPDP is a safe and feasible surgical approach with good short- and long-term outcomes.