Scholarlink

Purpose <p>The objective of this study was to evaluate the functional and clinical outcome of submacular hemorrhage in age-related macular degeneration (ARMD) using pneumatic displacement with intravitreal expansile gas by 23Gauge pars plana vitrectomy with subretinal injection of recombinant tissue plasminogen activator (rtPA) 50&#xa0;mg in 0.1&#xa0;ml.</p> Patients and Methods <p>Retrospective interventional case series of 58 pseudophakic patients, who underwent surgical treatment with inclusion criteria: subretinal, subretinal pigment epithelium (subRPE), or combined central hemorrhage associated with ARMD, 23 Gauge pars plana vitrectomy using rtPA sulfur hexafluoride (SF6 20%). Medical records were reviewed for logMAR best corrected visual acuity (BCVA), clinical findings, complications, and medical history up to 6&#xa0;months after surgery.</p> Results <p>Patients were classified with small hemorrhage up to 2 × 2 papillary diameter (PD) in 32 eyes, moderate hemorrhage (up to 4 × 4PD, to the arcades) in 19 eyes and massive hemorrhage (from 5 × 5PD hemorrhage through the arcades to the periphery) in 7 eyes. Improvement of average postoperative BCVA was the best in the group with moderate extension of hemorrhage, 1.58 logMAR preoperative to 1.14 logMAR postoperative. Regarding the association between the hemorrhage category and clinical outcome, there was a significant positive association between the hemorrhage size before the operation and the scored clinical outcome.</p> Conclusion <p>Anticoagulants are associated with massive hemorrhage and, at the same time, with better postoperative BCVA than massive hemorrhage without total anticoagulant treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Surgical Treatment of Hemorrhagic Complications of Age-Related Macular Degeneration, Predictive Factors and Outcomes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月3日

查看全文
  • Jela Valaskova,
  • Pavol Vesely,
  • Vladimir Krasnik,
  • Ivajlo Popov,
  • Jan Juhas,
  • Iveta Waczulikova,
  • Alena Furdova

摘要

Purpose

The objective of this study was to evaluate the functional and clinical outcome of submacular hemorrhage in age-related macular degeneration (ARMD) using pneumatic displacement with intravitreal expansile gas by 23Gauge pars plana vitrectomy with subretinal injection of recombinant tissue plasminogen activator (rtPA) 50 mg in 0.1 ml.

Patients and Methods

Retrospective interventional case series of 58 pseudophakic patients, who underwent surgical treatment with inclusion criteria: subretinal, subretinal pigment epithelium (subRPE), or combined central hemorrhage associated with ARMD, 23 Gauge pars plana vitrectomy using rtPA sulfur hexafluoride (SF6 20%). Medical records were reviewed for logMAR best corrected visual acuity (BCVA), clinical findings, complications, and medical history up to 6 months after surgery.

Results

Patients were classified with small hemorrhage up to 2 × 2 papillary diameter (PD) in 32 eyes, moderate hemorrhage (up to 4 × 4PD, to the arcades) in 19 eyes and massive hemorrhage (from 5 × 5PD hemorrhage through the arcades to the periphery) in 7 eyes. Improvement of average postoperative BCVA was the best in the group with moderate extension of hemorrhage, 1.58 logMAR preoperative to 1.14 logMAR postoperative. Regarding the association between the hemorrhage category and clinical outcome, there was a significant positive association between the hemorrhage size before the operation and the scored clinical outcome.

Conclusion

Anticoagulants are associated with massive hemorrhage and, at the same time, with better postoperative BCVA than massive hemorrhage without total anticoagulant treatment.