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<p>The effect of the administration of different doses of jaboticaba peel phenolic extract (JPPE) on serum biomarkers of hepatic, pancreatic, renal, and oxidative stress and the development of hepatic steatosis in rabbits was evaluated. In this trial, 36 rabbits were divided into six groups: control, hypercholesterolemic diet (HD), HD + 0.4&#xa0;mg JPPE·kg·day<sup>−1</sup>, HD + 0.8&#xa0;mg JPPE·kg·day<sup>−1</sup>, HD + 0.8&#xa0;mg JPPE·kg·day<sup>−1</sup> on alternate days and HD + 0.3&#xa0;mg simvastatin·kg·day<sup>−1</sup>. JPPE consumption reduced levels of lipase and gamma-glutamyltransferase, prevented lipid peroxidation, and stimulated the activity of antioxidant enzymes in the animals’ livers. In addition, it was demonstrated that JPPE supplementation attenuates steatosis in hepatic tissue&#xa0;of rabbits. Therefore, the daily consumption of jaboticaba peel or its phenolic extract can prevent the oxidative and pancreatic damage generated by a hypercholesterolemic diet and the development of non-alcoholic fatty liver disease in rabbits.</p>

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From peel to health: jaboticaba’s phenolics counteract oxidative stress and liver fat buildup

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月10日

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  • Kéllen Wanessa Coutinho Viana,
  • Larissa Lorrane Rodrigues Borges,
  • Amanda Lais Alves Almeida Nascimento,
  • Thaís Caroline Buttow Rigolon,
  • Nathália de Andrade Neves,
  • Sérgio Luis Pinto da Matta ,
  • Daiana Wischral,
  • Evandro Martins,
  • Pedro Henrique Campelo,
  • Paulo César Stringheta

摘要

The effect of the administration of different doses of jaboticaba peel phenolic extract (JPPE) on serum biomarkers of hepatic, pancreatic, renal, and oxidative stress and the development of hepatic steatosis in rabbits was evaluated. In this trial, 36 rabbits were divided into six groups: control, hypercholesterolemic diet (HD), HD + 0.4 mg JPPE·kg·day−1, HD + 0.8 mg JPPE·kg·day−1, HD + 0.8 mg JPPE·kg·day−1 on alternate days and HD + 0.3 mg simvastatin·kg·day−1. JPPE consumption reduced levels of lipase and gamma-glutamyltransferase, prevented lipid peroxidation, and stimulated the activity of antioxidant enzymes in the animals’ livers. In addition, it was demonstrated that JPPE supplementation attenuates steatosis in hepatic tissue of rabbits. Therefore, the daily consumption of jaboticaba peel or its phenolic extract can prevent the oxidative and pancreatic damage generated by a hypercholesterolemic diet and the development of non-alcoholic fatty liver disease in rabbits.