A highly selective fluorescent chemosensor for turn-on recognition of Zn²⁺ and turn-off recognition of Cu²⁺ ions with applications in real samples, molecular logic gate and cell imaging studies

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2026年5月11日

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S. Priyalakshmi Devi,
Nayan Roy,
Abhijit Dutta,
Dharmeshwar Barhoi,
Sarbani Giri,
T. Sanjoy Singh

摘要

In this research work, we have successfully designed and developed a Schiff base fluorescent chemosensor for detecting Zn²⁺ and Cu²⁺ ions using absorption and fluorescence spectroscopy. A stable complex formation of L with Zn²⁺ was observed with a noticeable isosbestic point in the absorption spectra. Moreover, fluorescence “on-off” response with Zn²⁺ and Cu²⁺ was observed which indicates selectively senses of Zn²⁺ and Cu²⁺. This sensor displays 1:1 stoichiometric ratio with metal ions by ¹H NMR titration, mass spectra, BH-plot and Job’s plot. Moreover, the recyclability of L was assessed through EDTA showing an efficient fluorescence “off-on-off” signal response. Furthermore, the (L+Zn²⁺) ensemble formed was used for selective recognize F⁻ ion. L achieved an INHIBIT logic function using different chemical inputs and corresponding emission as output. The optimized structures of L and complexes (L+Zn²⁺ and L+Cu²⁺) were used to understand spectral properties using DFT which further calculated different reactivity descriptors. This selective sensitivity of L towards Zn²⁺ were successfully studied and used for detection of Zn²⁺ intracellularly in mouse breast adenocarcinoma cell.

A highly selective fluorescent chemosensor for turn-on recognition of Zn2+ and turn-off recognition of Cu2+ ions with applications in real samples, molecular logic gate and cell imaging studies

摘要

A highly selective fluorescent chemosensor for turn-on recognition of Zn²⁺ and turn-off recognition of Cu²⁺ ions with applications in real samples, molecular logic gate and cell imaging studies