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<p>Cancer, distinguished by the uncontrolled proliferation and spread of malignantly altered cells, poses a substantial worldwide health concern. The complex series of events in cancer progression entails intricate molecular and genetic changes occurring within specific cellular targets. Cancer chemoprevention has emerged as a crucial approach to alleviate the burden of cancer on healthcare systems. This strategy involves the utilization of pharmacologically natural molecules and active substances to impede, suppress, forestall, or reverse the progression of invasive cancer. Among these substances, <i>Vernonia amygdalina Delile (VAD</i>) demonstrated therapeutic properties. This review elicits the detailed potential of <i>VAD</i> in combating multiple cancers by targeting cancer pathways. <i>VAD</i> has demonstrated noteworthy preventive capabilities by inhibiting cellular growth, migration, and invasion of cancer cells, stimulating cell death, and regulating signaling routes associated with cancer initiation. Furthermore, the <i>VAD</i>'s leaf extract has been identified to contain bioactive molecules that contribute to its cytotoxic, antioxidant, and anticancer activities. Despite progress in the exploration of <i>VAD</i>'s chemopreventive attributes, there are shortcomings in both in vivo studies and individual molecular scrutiny. Future research efforts should emphasize in vivo experimentation and clinical trials while carefully delineating the signaling pathways involved.</p>

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Vernonia amygdalina Delile and cancer: a comprehensive review of its chemopreventive mechanisms and efficacy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月30日

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  • Martin Ndayambaje,
  • Thierry Habyarimana,
  • Theogene Niyonsaba,
  • Aimable Mwiseneza,
  • Jean Paul Nshizirungu,
  • Callixte Yadufashije,
  • Abdallah Naya,
  • Mounia Oudghiri

摘要

Cancer, distinguished by the uncontrolled proliferation and spread of malignantly altered cells, poses a substantial worldwide health concern. The complex series of events in cancer progression entails intricate molecular and genetic changes occurring within specific cellular targets. Cancer chemoprevention has emerged as a crucial approach to alleviate the burden of cancer on healthcare systems. This strategy involves the utilization of pharmacologically natural molecules and active substances to impede, suppress, forestall, or reverse the progression of invasive cancer. Among these substances, Vernonia amygdalina Delile (VAD) demonstrated therapeutic properties. This review elicits the detailed potential of VAD in combating multiple cancers by targeting cancer pathways. VAD has demonstrated noteworthy preventive capabilities by inhibiting cellular growth, migration, and invasion of cancer cells, stimulating cell death, and regulating signaling routes associated with cancer initiation. Furthermore, the VAD's leaf extract has been identified to contain bioactive molecules that contribute to its cytotoxic, antioxidant, and anticancer activities. Despite progress in the exploration of VAD's chemopreventive attributes, there are shortcomings in both in vivo studies and individual molecular scrutiny. Future research efforts should emphasize in vivo experimentation and clinical trials while carefully delineating the signaling pathways involved.