<p><i>Blumea eriantha</i> DC., a lesser-known member of the Asteraceae family, has received increased interest in recent years due to its various pharmacological activities and possible medicinal applications. Traditionally used in Indian ethnomedicine for treating wounds, inflammation, and skin disorders, this plant is now scientifically validated for a broad range of bioactivities. Phytochemical analyses have identified flavonoids, terpenoids, phenolics, and essential oils exhibiting significant antioxidant, anti-inflammatory, anticancer, antibacterial, and larvicidal activities. Notably, methanolic extracts and essential oils from <i>B.eriantha</i> have demonstrated cytotoxic effects on various cancer cell lines, significant wound healing activity, and inhibition of angiogenesis. In addition, recent research has investigated the utilization of plant extracts to synthesize silver and iron nanoparticles, which exhibited enhanced biological efficacy, including hair growth promotion and apoptosis induction in cancer cells. Despite these encouraging findings, <i>B.eriantha</i> remains underexplored in terms of its mechanistic pathways, clinical validation, and standardization of bioactive compounds. This review aims to critically assess the therapeutic landscape of <i>B.eriantha</i>, highlighting its phytochemical diversity, pharmacological relevance, and the need for further research to unlock its full medicinal potential.</p> Graphical Abstract <p></p>