Scholarlink

<p>This study presents a detailed investigation of the interaction between the ionic liquid 1-hexyl-3-methylimidazolium chloride (HmimCl) and an antibiotic cloxacillin sodium (CLX). Binding interactions were explored using both equilibrium and dynamic surface tension measurements at temperatures of 298&#xa0;K, 303&#xa0;K, and 308&#xa0;K. The equilibrium surface tension method was utilized to study the interfacial and thermodynamic properties of micellization of pure HmimCl and HmimCl-CLX at the air-water interface. Dynamic surface tension measurements were carried out for both HmimCl and HmimCl-CLX systems over time. These measurements helped assess the influence of the DST values and other related kinetic parameters for both systems. Additionally, dynamic light scattering was used to determine the hydrodynamic diameter (D<sub>h</sub>) of HmimCl aggregates and the drug-loaded micelles. The stability of the HmimCl-CLX complex was assessed through zeta (ζ) potential measurements, where a decrease in ζ values indicated that the interaction between HmimCl and CLX is primarily electrostatic in nature. Furthermore, the interaction between CLX and HmimCl was quantitatively examined using steady-state fluorescence and UV-visible spectroscopy. To complement and validate these experimental observations, classical density functional theory (DFT) calculations were also performed. Together, the combined spectroscopic, dynamic, and theoretical analyses provide strong evidence of a stable and energetically favorable interaction between CLX and HmimCl, highlighting their potential for drug delivery or molecular binding applications.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Physicochemical and DFT study on the binding analysis of cloxacillin sodium with imidazolium ionic liquid

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月11日

查看全文
  • Md. Abrar Siddiquee,
  • Ab. Raouf Bhat,
  • Yogesh Kumar,
  • Farooq Ahmad Wani,
  • Aashima Anand,
  • Rajan Patel

摘要

This study presents a detailed investigation of the interaction between the ionic liquid 1-hexyl-3-methylimidazolium chloride (HmimCl) and an antibiotic cloxacillin sodium (CLX). Binding interactions were explored using both equilibrium and dynamic surface tension measurements at temperatures of 298 K, 303 K, and 308 K. The equilibrium surface tension method was utilized to study the interfacial and thermodynamic properties of micellization of pure HmimCl and HmimCl-CLX at the air-water interface. Dynamic surface tension measurements were carried out for both HmimCl and HmimCl-CLX systems over time. These measurements helped assess the influence of the DST values and other related kinetic parameters for both systems. Additionally, dynamic light scattering was used to determine the hydrodynamic diameter (Dh) of HmimCl aggregates and the drug-loaded micelles. The stability of the HmimCl-CLX complex was assessed through zeta (ζ) potential measurements, where a decrease in ζ values indicated that the interaction between HmimCl and CLX is primarily electrostatic in nature. Furthermore, the interaction between CLX and HmimCl was quantitatively examined using steady-state fluorescence and UV-visible spectroscopy. To complement and validate these experimental observations, classical density functional theory (DFT) calculations were also performed. Together, the combined spectroscopic, dynamic, and theoretical analyses provide strong evidence of a stable and energetically favorable interaction between CLX and HmimCl, highlighting their potential for drug delivery or molecular binding applications.

Graphical Abstract