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<p>This study aims to synthesis new chemical compounds via the combination of some amino acids glutamine, asparagine, histidine, arginine and glycine by Schiff base reactions using phthaldehyde. The principle aims to synthesis compounds of some Schiff base compounds which prepared by the reactions between phthalaldehyde and various amino acids. Also to study some of biological applications anti-Cancer, anti-Fungi and anti-inflammatory of the study Schiff base compound. The biological investigation of the resulting compounds including determination of sample cytotoxicity on cells (MTT protocol), effect of complexes on HRBC hemolytic and membrane stabilization &amp; In-vitro antimicrobial activities on 5 species of Fungi.</p>

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Design, synthesis, molecular modeling and biological investigation of glutamine, asparagine, histidine, arginine and glycine linked Schiff base derivatives as potential anticancer and antifungal agents

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月21日

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  • Hamad M. A. Hasan,
  • Hanan A. Khalied,
  • Somia M. A. Elsheihi,
  • Emad M. Othman,
  • Ahmed K. Al-Kubeisi,
  • Mohamed G. Bekhit

摘要

This study aims to synthesis new chemical compounds via the combination of some amino acids glutamine, asparagine, histidine, arginine and glycine by Schiff base reactions using phthaldehyde. The principle aims to synthesis compounds of some Schiff base compounds which prepared by the reactions between phthalaldehyde and various amino acids. Also to study some of biological applications anti-Cancer, anti-Fungi and anti-inflammatory of the study Schiff base compound. The biological investigation of the resulting compounds including determination of sample cytotoxicity on cells (MTT protocol), effect of complexes on HRBC hemolytic and membrane stabilization & In-vitro antimicrobial activities on 5 species of Fungi.